{"id":90941,"date":"2019-01-18T07:30:44","date_gmt":"2019-01-17T22:30:44","guid":{"rendered":"https:\/\/www.ishamachi.com\/?p=90941"},"modified":"2019-08-22T17:02:48","modified_gmt":"2019-08-22T08:02:48","slug":"%e3%80%8c%e6%95%b5%e3%82%92%e7%9f%a5%e3%82%8a%e3%80%81%e5%b7%b1%e3%82%92%e7%9f%a5%e3%82%8c%e3%81%b0%e3%80%81%e7%99%be%e6%88%a6%e5%8d%b1%e3%81%86%e3%81%8b%e3%82%89%e3%81%9a%e3%80%8d-%e3%83%a9%e3%83%b3","status":"publish","type":"post","link":"https:\/\/www.ishamachi.com\/?p=90941","title":{"rendered":"\u300c\u6575\u3092\u77e5\u308a\u3001\u5df1\u3092\u77e5\u308c\u3070\u3001\u767e\u6226\u5371\u3046\u304b\u3089\u305a\u300d \u30e9\u30f3\u30b2\u30eb\u30cf\u30f3\u30b9\u7d30\u80de\u7d44\u7e54\u7403\u75c7\uff08LCH\uff09\u306e\u6b63\u4f53\u306f\u4f55\uff1f"},"content":{"rendered":"

\uff11\uff0e\u201cwait and see\u201d<\/h2>\n

LCH\u306e\u6cbb\u7642\u306b\u3064\u3044\u3066\u66f8\u304b\u308c\u305f\u8ad6\u6587\u306b\u306f\u201cwait and see\u201d\u3068\u3044\u3046\u8a00\u8449\u304c\u3088\u304f\u51fa\u3066\u304d\u307e\u3059\u3002\u201cwait and see\u201d\u3092\u3001\u611b\u7528\u306eWeb\u8f9e\u66f8\u300e\u82f1\u8f9e\u90ce\u300f\u3067\u691c\u7d22\u3059\u308b\u3068\u3001\u300c\u6210\u308a\u884c\u304d\u3092\u898b\u5b88\u308b\u3001\u5f62\u52e2\u3092\u3046\u304b\u304c\u3046\u3001\u69d8\u5b50\u3092\u898b\u308b\u3001\u9759\u89b3\u3059\u308b\u3001\u65e5\u548c\u898b\u3059\u308b\u300d\u3068\u51fa\u3066\u304d\u307e\u3059\u3002<\/p>\n

\u6cbb\u7642\u3092\u3057\u306a\u304f\u3066\u3082\u81ea\u7136\u306b\u3088\u304f\u306a\u308b\u3053\u3068\u3082\u3042\u308b\u306e\u3067\u3001LCH\u306e\u6cbb\u7642\u306b\u969b\u3057\u3066\u306f\u3001\u201cwait and see\u201d\u3082\u3042\u308a\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u305f\u3060\u773a\u3081\u3066\u3044\u308b\u3060\u3051\u3067\u306f\u3001\u300c\u30dc\u30fc\u3063\u3068\u751f\u304d\u3066\u3093\u3058\u3083\u306d\u30fc\u3088\u300d\u3068\u3001\u30c1\u30b3\u3061\u3083\u3093\u306b\u53f1\u3089\u308c\u307e\u3059\u3002\u30c1\u30b3\u3061\u3083\u3093\u306b\u53f1\u3089\u308c\u306a\u3044\u3088\u3046\u306b\u3001\u304a\u533b\u8005\u3055\u3093\u306f\u3057\u3063\u304b\u308aLCH\u60a3\u8005\u3055\u3093\u3092\u8a3a\u306a\u3044\u3068\u3044\u3051\u307e\u305b\u3093\u3002<\/p>\n

\uff12\uff0e\u201cunknown etiology\u201d<\/h2>\n

LCH\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u306e\u5192\u982d\u306b\u306f\u5fc5\u305a\u3068\u8a00\u3063\u3066\u3044\u3044\u307b\u3069\u3001LCH\u306f\u201c<\/strong>unknown etiology<\/strong>\u201d<\/strong>\u3060\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002\u201cunknown etiology\u201d\u3092\u307e\u305f\u307e\u305f\u300e\u82f1\u8f9e\u90ce\u300f\u3067\u691c\u7d22\u3057\u3066\u307f\u308b\u3068\u3001\u300c\u539f\u56e0\u4e0d\u660e\u300d<\/strong>\u3068\u51fa\u3066\u304d\u307e\u3059\u3002<\/p>\n

\u3055\u3066\u3055\u3066\u3001LCH\u306e\u6b63\u4f53\u304c\u306f\u3063\u304d\u308a\u3057\u306a\u3044\u3053\u3068\u306b\u306f\u3001\u3069\u306e\u3088\u3046\u306b\u6cbb\u7642\u3092\u3057\u3066\u3044\u3044\u304b\u308f\u304b\u308a\u307e\u305b\u3093\u3002LCH\u3068\u3044\u3046\u75c5\u540d\u304c\u4f5c\u3089\u308c\u305f1987\u5e74\u307e\u3067\u306f\u3001\u3053\u306e\u75c5\u6c17\u306fHistiocytosis X<\/strong>\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u7d44\u7e54\u7403\u304c\u96c6\u307e\u3063\u3066\u60aa\u3055\u3092\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u308f\u304b\u3063\u3066\u3044\u305f\u306e\u3067\u3059\u304c\u3001\u305d\u306e\u6b63\u4f53\u306f\u4e0d\u660e\u3060\u3063\u305f<\/strong>\u306e\u3067\u3059\u3002\u5b66\u751f\u306e\u6642\u3001\u79c1\u306e\u89aa\u53cb\u306f\u3053\u306e\u75c5\u540d\u3092\u805e\u3044\u3066\u300c\u75c5\u540d\u306bX\u3068\u306f\u4f55\u305e\u3084\uff1f\u3000\u30de\u30eb\u30b3\u30e0X\u306a\u3089\u805e\u3044\u305f\u3053\u3068\u3042\u308b\u3051\u308c\u3069\u300d\u3068\u8a00\u3044\u307e\u3057\u305f\u3002<\/p>\n

LCH\u306e\u75c5\u540d\u306b\u5909\u308f\u3063\u3066\u304b\u308930\u5e74\u4ee5\u4e0a\u304c\u7d4c\u904e\u3057\u3001\u3088\u3046\u3084\u304f\u201cX\u201d\u306e\u6b63\u4f53\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u307e\u305a\u306f\u3001LCH\u306e\u6b63\u4f53\u306f\u4f55\u306a\u306e\u304b<\/strong>\u306b\u3064\u3044\u3066\u8003\u3048\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n

\uff13\uff0eLCH\u3063\u3066\u300c\u304c\u3093\u300d\u306a\u306e\uff1f<\/h2>\n

LCH\u306f\u300c\u304c\u3093\u300d\u306a\u306e\u304b\uff1f\u3053\u306e\u554f\u3044\u306b\u3064\u3044\u3066\u306f\u9577\u5e74\u8b70\u8ad6\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u73fe\u5728\u306fLCH\u306f\u300c\u708e\u75c7\u6027\u9aa8\u9ac4\u816b\u760d\u300d<\/strong>\u3068\u547c\u3070\u308c\u3001\u300c\u708e\u75c7\u300d\u3068\u300c\u304c\u3093\u300d\u306e\u6027\u683c\u3092\u4f75\u305b\u6301\u3063\u305f\u75c5\u6c17<\/strong>\u3060\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u300c\u708e\u75c7\u300d\u3068\u306f\u3001\u4f53\u3092\u75c5\u539f\u4f53\u304b\u3089\u5b88\u308b\u514d\u75ab\u306e\u53cd\u5fdc\u304c\u6d3b\u767a\u306b\u306a\u3063\u305f\u72b6\u614b\u3067\u3059\u3002\u3067\u306f\u3001\u4e00\u4f53\u300c\u304c\u3093\u300d\u3063\u3066\u4f55\u306a\u306e\u3067\u3057\u3087\u3046\uff1f<\/strong><\/p>\n

\u4e00\u822c\u7684\u306a\u300c\u304c\u3093\u300d\u306e\u30a4\u30e1\u30fc\u30b8\u3068\u3057\u3066\u306f\u3001\u300c\u6016\u3044\u75c5\u6c17\u300d\u3001\u300c\u624b\u9045\u308c\u306b\u306a\u308b\u3068\u306a\u304a\u3089\u306a\u3044\u300d\u3001\u300c\u8ee2\u79fb\u3059\u308b\u3068\u306a\u304a\u3089\u306a\u3044\u300d\u3001\u300c\u518d\u767a\u3059\u308b\u3068\u304a\u5148\u771f\u3063\u6697\u300d\u3001\u300c\u6700\u5f8c\u306f\u6b7b\u3093\u3067\u3057\u307e\u3046\u300d\u306a\u3069\u3068\u601d\u308f\u308c\u308b\u3067\u3057\u3087\u3046\u3002\u3057\u304b\u3057LCH\u306e\u60a3\u8005\u3055\u3093\u306f\u3001\u3054\u304f\u305f\u307e\u306b\u6025\u6fc0\u306b\u75c5\u72b6\u304c\u60aa\u5316\u3057\u3066\u4ea1\u304f\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u6cbb\u7642\u3057\u306a\u304f\u3066\u3082\u81ea\u7136\u306b\u306a\u304a\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3057\u3001\u518d\u767a\u3057\u3066\u3082\u591a\u304f\u306e\u5834\u5408\u306f\u521d\u3081\u306b\u53d7\u3051\u305f\u6cbb\u7642\u304c\u518d\u3073\u52b9\u3044\u3066\u306a\u304a\u308a\u307e\u3059\u3002<\/strong>\u3088\u3063\u3066\u3001\u4e00\u822c\u7684\u306a\u300c\u304c\u3093\u300d\u306e\u30a4\u30e1\u30fc\u30b8\u304b\u3089\u306f\u304b\u3051\u96e2\u308c\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n

\uff14\uff0e\u300c\u304c\u3093\u300d\u3068\u3057\u3066\u306eLCH<\/h2>\n
\"LCH\u7d30\u80de\u3068\u300c\u304c\u3093\u300d\u7d30\u80de\u3068\u306e\u5171\u901a\u70b9\"<\/a><\/div>\n

\u4e00\u4f53\u300c\u304c\u3093\u300d\u3063\u3066\u4f55\u306a\u306e\uff1f\u3000\u3053\u306e\u554f\u3044\u306f\u3001\u308f\u304b\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3001\u3042\u3089\u305f\u3081\u3066\u554f\u308f\u308c\u308b\u3068\u3088\u304f\u308f\u304b\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u4e00\u822c\u306b\u300c\u304c\u3093\u300d\u7d30\u80de\u306f\u3001\u300c\u3069\u3093\u3069\u3093\u5897\u3048\u308b\u300d<\/strong>\u3068\u304b\u3001\u300c\u3057\u3076\u3068\u304f\u3066\u6b7b\u306a\u306a\u3044\u300d<\/strong>\u3068\u304b\u3001\u300c\u6b63\u5e38\u306a\u50cd\u304d\u3092\u3057\u306a\u3044\u300d<\/strong>\u3068\u304b\u306e\u6027\u8cea\u304c\u3042\u308a\u307e\u3059\u3002\u3044\u304f\u3064\u304b<\/u>\u306e\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8a2d\u8a08\u56f3\u3001\u3064\u307e\u308a\u907a\u4f1d\u5b50\u306b\u50b7\uff08\u5909\u7570\uff09\u304c\u3064\u304f<\/strong>\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u3082\u3068\u3082\u3068\u306f\u6b63\u5e38\u306a\u7d30\u80de\u304c\u3053\u306e\u3088\u3046\u306a\u6027\u8cea\u3092\u6301\u3063\u3066\u3057\u307e\u3063\u305f\u3082\u306e\u304c\u300c\u304c\u3093\u300d\u7d30\u80de<\/strong>\u3067\u3059\u3002\u3053\u306e\u300c\u304c\u3093\u300d\u7d30\u80de\u304c\u4f53\u306e\u4e2d\u306b\u306f\u3073\u3053\u3063\u3066\u3057\u307e\u3044\u3001\u672c\u6765\u306e\u5185\u81d3\u306e\u50cd\u304d\u304c\u3046\u307e\u304f\u3044\u304b\u306a\u304f\u306a\u308b\u306e\u304c\u300c\u304c\u3093\u300d\u3068\u3044\u3046\u75c5\u6c17<\/strong>\u3067\u3059\u3002<\/p>\n

\u3053\u3053\u304b\u3089\u5c11\u3057\u96e3\u3057\u304f\u306a\u308a\u307e\u3059\u3002\u30b7\u30ea\u30fc\u30ba\u306e\u7b2c1\u56de\u306e\u300cLCH\u306e\u539f\u56e0\u306f\uff1f\u300d<\/a>\u306b\u3082\u3042\u308b\u3088\u3046\u306b\u30012010\u5e74\u306b\u3001\u7d04\u534a\u6570\u306eLCH\u60a3\u8005\u3055\u3093\u306eLCH\u7d30\u80de\u306b\u306fBRAF<\/em><\/strong>\u907a\u4f1d\u5b50\u306b\u767a\u304c\u3093\u6027\u5909\u7570\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/strong>BRAF<\/em>\u907a\u4f1d\u5b50\u306f\u3001MAP\u30ad\u30ca\u30fc\u30bc\u7d4c\u8def\u3068\u3044\u3046\u7d30\u80de\u306e\u5897\u6b96\uff08\u3069\u3093\u3069\u3093\u5897\u3048\u308b\uff09\u3084\u751f\u5b58\uff08\u6b7b\u306a\u306a\u3044\uff09\u3001\u5206\u5316\uff08\u50cd\u304f\u80fd\u529b\u304c\u5099\u308f\u308b\uff09\u306a\u3069\u306b\u304b\u304b\u308f\u308b\u4fe1\u53f7\u3092\u30ea\u30ec\u30fc\u5f0f\u306b\u4f1d\u3048\u308b\u4ed5\u7d44\u307f<\/strong>\u3092\u62c5\u3046\u907a\u4f1d\u5b50\u306e\u3072\u3068\u3064\u3067\u3059\u3002<\/p>\n

\u767a\u304c\u3093\u6027\u5909\u7570\u3068\u306f\u3001\u304c\u3093\u306e\u6027\u8cea\u3092\u6301\u3064\u3088\u3046\u306b\u306a\u308b\u907a\u4f1d\u5b50\u306e\u50b7<\/strong>\u306e\u3053\u3068\u3092\u3044\u3044\u307e\u3059\u3002BRAF<\/em><\/strong>\u907a\u4f1d\u5b50\u306e\u767a\u304c\u3093\u6027\u5909\u7570\u306f\u3001\u591a\u304f\u306e\u300c\u304c\u3093\u300d\u7d30\u80de\u306b\u3057\u3070\u3057\u3070\u307f\u3089\u308c\u307e\u3059\u3002<\/strong>\u4f8b\u3048\u3070\u3001\u3042\u308b\u7a2e\u306e\u767d\u8840\u75c5\u3067\u306f100%\u3001\u76ae\u819a\u304c\u3093\u306e\u60aa\u6027\u9ed2\u8272\u816b\uff08\u30e1\u30e9\u30ce\u30fc\u30de\uff09\u3067\u306f60-70%\u3001\u3042\u308b\u7a2e\u306e\u7532\u72b6\u817a\u304c\u3093\u3067\u306f40-50%\u3001\u5927\u8178\u304c\u3093\u3067\u306f\u7d0410%\u306e\u60a3\u8005\u3055\u3093\u306bBRAF<\/em>\u907a\u4f1d\u5b50\u306e\u767a\u304c\u3093\u6027\u5909\u7570\u304c\u307f\u3089\u308c\u307e\u3059\u3002<\/p>\n

\"MAP\u30ad\u30ca\u30fc\u30bc\u7d4c\u8def\u306e\u7570\u5e38\"<\/a><\/div>\n

\u305d\u306e\u5f8c\u3001BRAF<\/em>\u4ee5\u5916\u306b\u3082MAP\u30ad\u30ca\u30fc\u30bc\u7d4c\u8def\u306e\u907a\u4f1d\u5b50\u306b\u6b21\u3005\u306b\u7570\u5e38\u304c\u898b\u3064\u304b\u308a\u307e\u3057\u305f\u3002\u4eca\u3067\u306f\u3001\u307b\u307c<\/strong>100\uff05\u306eLCH\u306e\u60a3\u8005\u3055\u3093\u306eLCH\u7d30\u80de\u306b\u306f\u3001\u3053\u306e\u7d4c\u8def\u306e\u3069\u3053\u304b\u306b\u7570\u5e38\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/strong>\u305d\u3057\u3066\u3001\u3053\u306e\u7d4c\u8def\u306e\u30b9\u30a4\u30c3\u30c1\u304c\u5e38\u306b<\/strong>\u201dON\u201d\u306b\u306a\u3063\u3066\u3044\u3066\u3001\u4fe1\u53f7\u304c\u52dd\u624b\u306b\u3069\u3093\u3069\u3093\u4f1d\u308f\u3063\u3066\u3057\u307e\u3063\u3066\u3044\u308b<\/strong>\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u300c\u907a\u4f1d\u5b50\u306b\u7570\u5e38\u304c\u8d77\u3053\u308a\u3001\u6b7b\u306a\u306a\u304f\u306a\u308b\uff08\u7d50\u679c\u3001\u305f\u304f\u3055\u3093\u96c6\u307e\u308b\uff09\u3001\u6b63\u5e38\u306a\u50cd\u304d\u3092\u3057\u306a\u304f\u306a\u308b\u300d\u3068\u3044\u3046\u3053\u3068\u304b\u3089\u3001LCH\u7d30\u80de\u306f\u300c\u304c\u3093\u300d\u7d30\u80de\u306e\u4ef2\u9593<\/strong>\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\uff15\uff0e\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u907a\u4f1d\u5b50\u306b\u50b7\u304c\u3064\u3044\u3066\u3057\u307e\u3046\u306e\u304b\uff1f<\/h2>\n

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\u30d2\u30c8\u306e\u4f53\u306b\u306f\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u50b7\u3092\u4fee\u6b63\u3057\u3066\u306a\u304a\u3059\u4ed5\u7d44\u307f\u304c\u5099\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u3088\u3063\u3066\u3001\u5c0f\u3055\u306a\u50b7\u306e\u5834\u5408\u306b\u306f\u4fee\u6b63\u3057\u3066\u5143\u306b\u623b\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3082\u3057\u5927\u304d\u306a\u50b7\u304c\u3064\u3044\u3066\u3057\u307e\u3063\u305f\u5834\u5408\u306b\u306f\u306a\u304a\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u50b7\u304c\u3042\u307e\u308a\u306b\u5927\u304d\u3044\u3068\u3001\u305d\u306e\u7d30\u80de\u306f\u751f\u304d\u3066\u3044\u308b\u3053\u3068\u304c\u3067\u304d\u305a\u6b7b\u3093\u3067\u3057\u307e\u3046\u306e\u3067\u3001\u300c\u304c\u3093\u300d\u7d30\u80de\u3068\u3057\u3066\u751f\u304d\u6b8b\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u554f\u984c\u3068\u306a\u308b\u306e\u306f\u3001\u7d30\u80de\u306e\u751f\u5b58\u3084\u5897\u6b96\u306b\u304b\u304b\u308f\u308b\u907a\u4f1d\u5b50\uff08\u3064\u307e\u308a\u3053\u308c\u304c\u300c\u304c\u3093\u300d\u907a\u4f1d\u5b50\uff09\u306b\u3001\u5927\u304d\u3059\u304e\u306a\u3044\u3051\u308c\u3069\u306a\u304a\u305b\u306a\u3044\u3088\u3046\u306a\u4e2d\u9014\u534a\u7aef\u306a\u50b7\u304c\u3064\u304d\u3001\u305d\u306e\u50b7\u304c\u3001\u7d30\u80de\u304c\u751f\u304d\u5ef6\u3073\u308b\u3053\u3068\u3084\u5897\u3048\u308b\u3053\u3068\u306b\u6709\u5229\u306b\u50cd\u304f\u3088\u3046\u306a\u5834\u5408<\/strong>\u3067\u3059\u3002\u305d\u306e\u3088\u3046\u306a\u6642\u3001\u907a\u4f1d\u5b50\u306b\u50b7\u3092\u6301\u3063\u305f\u7d30\u80de\u306f\u300c\u304c\u3093\u300d\u7d30\u80de\u3078\u306e\u9053\u3092\u6b69\u307f\u59cb\u3081\u307e\u3059\u3002<\/p>\n

\"\u907a\u4f1d\u5b50\u306e\u50b7\u304b\u3089\u300c\u304c\u3093\u300d\u306b\u306a\u308b\u307e\u3067\"<\/a><\/div>\n

\uff16\uff0e\u300c\u304c\u3093\u300d\u306f\u4e00\u591c\u306b\u3057\u3066\u306a\u3089\u305a<\/h2>\n

\u300c\u5c0f\u5150\u304c\u3093\u300d\u3068\u3044\u3046\u306e\u306f\u3082\u3061\u308d\u3093\u3042\u308a\u307e\u3059\u304c\u3001\u4e00\u822c\u306b\u300c\u304c\u3093\u300d\u3092\u767a\u75c7\u3057\u3084\u3059\u3044\u306e\u306f\u304a\u5e74\u5bc4\u308a\u3067\u3059\u3002\u305d\u308c\u306f\u306a\u305c\u3067\u3057\u3087\u3046\uff1f<\/p>\n

\u5148\u307b\u3069\u3001\u300e\u3044\u304f\u3064\u304b<\/u>\u306e\u907a\u4f1d\u5b50\u306b\u50b7\u300f\u304c\u3064\u3044\u3066\u300c\u304c\u3093\u300d\u306e\u6027\u8cea\u3092\u6301\u3064\u3088\u3046\u306b\u306a\u308b\u3068\u66f8\u304d\u307e\u3057\u305f\u304c\u3001\u3053\u306e\u300e\u3044\u304f\u3064\u304b<\/u>\u300f\u3068\u3044\u3046\u3068\u3053\u308d\u304c\u91cd\u8981\u306a\u306e\u3067\u3059\u3002<\/strong><\/p>\n

\u300c\u305f\u307e\u305f\u307e\u300d\u300c\u5076\u7136\u300d\u306b\u3067\u304d\u305f\u907a\u4f1d\u5b50\u306e\u50b7\u306f\u3001\u9577\u5e74\u751f\u304d\u3066\u3044\u308b\u3068\u84c4\u7a4d\u3057\u3066\u304d\u307e\u3059\u3002\u5148\u307b\u3069\u8ff0\u3079\u305f\u8907\u6570\u306e\u300c\u304c\u3093\u300d\u907a\u4f1d\u5b50\u306b\u904b\u60aa\u304f\u50b7\u304c\u7a4d\u307f\u91cd\u306a\u308b\u3068\u3001\u300c\u304c\u3093\u300d\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u3088\u3063\u3066\u3001\u5e74\u3092\u3068\u308b\u3068\u300c\u304c\u3093\u300d\u306b\u306a\u308b\u4eba\u306f\u5897\u3048\u3066\u3044\u304d\u307e\u3059\u3002<\/strong><\/p>\n

\u307e\u305f\u3001\u300c\u304c\u3093\u300d\u306f\u3001\u305d\u308c\u81ea\u4f53\u306e\u6027\u8cea\u3068\u3057\u3066\u50b7\u3064\u3044\u305f\u907a\u4f1d\u5b50\u3092\u306a\u304a\u305b\u306a\u3044<\/strong>\u3068\u3044\u3046\u7279\u5fb4\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u300c\u304c\u3093\u300d\u7d30\u80de\u306b\u3068\u3063\u3066\u8af8\u5203\u306e\u5263\u3067\u3059\u3002\u3064\u3044\u305f\u50b7\u3092\u306a\u304a\u305b\u305a\u300c\u304c\u3093\u300d\u7d30\u80de\u304c\u6b7b\u3093\u3067\u3057\u307e\u3046<\/strong>\u3053\u3068\u3082\u3042\u308b\u4e00\u65b9\u3001\u300c\u304c\u3093\u300d\u907a\u4f1d\u5b50\u306b\u50b7\u304c\u3064\u304f\u3053\u3068\u306b\u3088\u3063\u3066\u3088\u308a\u60aa\u3044\u6027\u8cea\u3001\u3064\u307e\u308a\u300c\u304c\u3093\u300d\u7d30\u80de\u304c\u751f\u304d\u6b8b\u308b\u306e\u306b\u597d\u90fd\u5408\u306a\u6027\u8cea\u3092\u7372\u5f97\u3057\u3066\u3057\u307e\u3046\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/strong><\/p>\n

\u5b9f\u969b\u306e\u3068\u3053\u308d\u306f\u3001\u751f\u5b58\u7af6\u4e89\u306b\u6253\u3061\u52dd\u3063\u305f\u3001\u3088\u308a\u5f37\u3044\uff08\u3088\u308a\u60aa\u6027\u5ea6\u304c\u9ad8\u3044\uff09\u300c\u304c\u3093\u300d\u7d30\u80de\u304c\u751f\u304d\u306a\u304c\u3089\u3048\u3066\u3069\u3093\u3069\u3093\u5897\u3048\u308b\u305f\u3081\u3001\u300c\u304c\u3093\u300d\u306b\u3068\u3063\u3066\u306f\u907a\u4f1d\u5b50\u306b\u3064\u3044\u305f\u50b7\u3092\u306a\u304a\u3055\u306a\u3044\u307b\u3046\u304c\u6709\u5229\u306b\u306a\u308a\u307e\u3059\u3002<\/strong><\/p>\n

\"\u300c\u304c\u3093\u300d\u306f\u4e00\u591c\u306b\u3057\u3066\u306a\u3089\u305a\"<\/a><\/div>\n

\u4e00\u822c\u306b\u3001\u300c\u304c\u3093\u300d\u3067\u306f\u3001\u591a\u304f\u306e\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u7a4d\u307f\u91cd\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/strong>LCH\u3068\u540c\u69d8\u306bBRAF<\/em>\u907a\u4f1d\u5b50\u306b\u767a\u304c\u3093\u6027\u5909\u7570\u3092\u6301\u3064\u300c\u304c\u3093\u300d\u3092\u898b\u3066\u307f\u3066\u3082\u3001\u30e1\u30e9\u30ce\u30fc\u30de\u3067\u306f\u4e00\u3064\u306e\u300c\u304c\u3093\u300d\u7d30\u80de\u306b\u7d04300\u500b\u3001\u5927\u8178\u304c\u3093\u3067\u306f\u657010\u500b\u306e\u50b7\u304c\u3064\u3044\u3066\u3044\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3068\u3053\u308d\u304c\u3001LCH\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u306e\u50b7\u306e\u6570\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3001MAP\u30ad\u30ca\u30fc\u30bc\u7d4c\u8def\u306e\u907a\u4f1d\u5b50\u306b\u305f\u3060<\/strong>1<\/strong>\u500b\u3060\u3051<\/strong>\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\uff17\uff0eBRAF<\/em>\u5909\u7570\u306f\u9ed2\u5b50\uff08\u307b\u304f\u308d\uff09\u306b\u3082\u3042\u308b<\/h2>\n

\u5148\u307b\u3069\u3001LCH<\/strong>\u7d30\u80de\u306b\u8a8d\u3081\u3089\u308c\u308bBRAF<\/em><\/strong>\u5909\u7570\u306f\u767a\u304c\u3093\u6027\u5909\u7570<\/strong>\u3068\u66f8\u304d\u307e\u3057\u305f\u304c\u3001\u5b9f\u306f\u7686\u3055\u3093\u304c\u4e00\u3064\u3084\u4e8c\u3064\u5fc5\u305a\u6301\u3063\u3066\u3044\u308b\u76ae\u819a\u306e\u9ed2\u5b50\u306b\u3082BRAF<\/em>\u907a\u4f1d\u5b50\u306e\u767a\u304c\u3093\u6027\u5909\u7570\u304c\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u624b\u306e\u3072\u3089\u3084\u8db3\u306e\u88cf\u306b\u3067\u304d\u305f\u9ed2\u5b50\u306f\u3001\u60aa\u6027\u5316\u3057\u3066\u76ae\u819a\u300c\u304c\u3093\u300d\u3001\u30e1\u30e9\u30ce\u30fc\u30de\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u3075\u3064\u3046\u9ed2\u5b50\u306f\u9ed2\u5b50\u3067\u3001\u9ed2\u5b50\u3092\u300c\u304c\u3093\u300d\u3068\u3044\u3046\u4eba\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u4e00\u65b9\u3001\u30e1\u30e9\u30ce\u30fc\u30de\u306f\u5168\u8eab\u306b\u5e83\u304c\u308b\u660e\u3089\u304b\u306a\u76ae\u819a\u300c\u304c\u3093\u300d\u3067\u3001\u524d\u8ff0\u306e\u3088\u3046\u306bBRAF<\/em>\u907a\u4f1d\u5b50\u306b\u767a\u304c\u3093\u6027\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3067\u306f\u3001\u9ed2\u5b50\u3068\u30e1\u30e9\u30ce\u30fc\u30de\u306e\u9055\u3044\u306f\u4f55\u306b\u3088\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u3000\u305d\u308c\u306f\u3001\u5909\u7570\u3057\u3066\u3044\u308b\u907a\u4f1d\u5b50\u306e\u6570<\/strong>\u306a\u306e\u3067\u3059\u3002\u9ed2\u5b50\u306f\u30e1\u30e9\u30ce\u30fc\u30de\u3068\u9055\u3063\u3066\u3001BRAF<\/em>\u907a\u4f1d\u5b50\u4ee5\u5916\u306b\u5909\u7570\u3057\u3066\u3044\u308b\u907a\u4f1d\u5b50\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3002BRAF<\/em>\u907a\u4f1d\u5b50\u306f\u78ba\u304b\u306b\u300c\u304c\u3093\u300d\u907a\u4f1d\u5b50\u306a\u306e\u3067\u3059\u304c\u3001\u305d\u308c\u3057\u304b\u7570\u5e38\u304c\u306a\u3044\u5834\u5408\u306b\u306f\u3001\u300c\u304c\u3093\u907a\u4f1d\u5b50\u8a98\u5c0e\u8001\u5316\u300d<\/strong>\u3068\u3044\u3046\u73fe\u8c61\u304c\u8d77\u304d\u3066\u3001\u305d\u306e\u7d30\u80de\u306f\u751f\u304d\u306a\u304c\u3089\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u304f\u306a\u308a\u307e\u3059\u3002<\/strong>\u3088\u3063\u3066\u3001\u9ed2\u5b50\u306f\u9ed2\u5b50\u3067\u3001\u30e1\u30e9\u30ce\u30fc\u30de\u3067\u306f\u306a\u3044\u308f\u3051\u3067\u3059\u3002<\/p>\n

\u3067\u306f\u3001\u306a\u305c\u3001\u9ed2\u5b50\u3068\u540c\u69d8\u306b\u4e00\u3064\u306e\u304c\u3093\u907a\u4f1d\u5b50\u306b\u3057\u304b\u50b7\u304c\u306a\u3044<\/strong>LCH\u7d30\u80de\u306f\u75c5\u5909\u90e8\u306b\u96c6\u307e\u3063\u3066\u3001\u300c\u75c5\u6c17\u300d\u306e\u75c7\u72b6\u304c\u51fa\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/strong><\/p>\n

\uff18\uff0e\u672a\u719f\u6a39\u72b6\u7d30\u80de\u3063\u3066\u4f55\uff1f<\/h2>\n

LCH\u7d30\u80de\u306f\u672a\u719f\u6a39\u72b6\u7d30\u80de<\/strong>\u306e\u6027\u8cea\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u672a\u719f\u6a39\u72b6\u7d30\u80de\u3068\u306f\u4f55\u3067\u3057\u3087\u3046\uff1f<\/p>\n

\u8840\u6db2\u4e2d\u306e\u767d\u8840\u7403\u306b\u306f\u9aa8\u9ac4\u7cfb\u3068\u30ea\u30f3\u30d1\u7cfb\u306e\u5927\u304d\u304f2\u7a2e\u985e\u304c\u3042\u308a\u3001\u672a\u719f\u6a39\u72b6\u7d30\u80de\u306f\u9aa8\u9ac4\u7cfb\u306e\u767d\u8840\u7403\u306e\u4e00\u7a2e<\/strong>\u3067\u3059\u3002\u5916\u6575\u306e\u4fb5\u5165\u3092\u7d76\u3048\u305a\u898b\u5f35\u3063\u3066\u3044\u308b\u756a\u4eba\u306e\u5f79\u5272<\/strong>\u3092\u3057\u3066\u3044\u307e\u3059\u3002\u5916\u754c\u3068\u5e38\u306b\u63a5\u89e6\u3057\u3066\u3044\u308b\u76ae\u819a\u306f\u5916\u304b\u3089\u306e\u4fb5\u5165\u8005\u304c\u6700\u3082\u591a\u3044\u90e8\u4f4d\u306a\u306e\u3067\u3001\u672a\u719f\u6a39\u72b6\u7d30\u80de\u306f\u3082\u3068\u3082\u3068\u76ae\u819a\u306b\u591a\u304f\u3044\u307e\u3059\u3002<\/strong>\u5916\u304b\u3089\u6575\u304c\u4fb5\u5165\u3057\u305f\u6642\u306b\u306f\u3001\u3059\u3050\u3055\u307e\u514d\u75ab\u7cfb<\/strong>\u3001\u3059\u306a\u308f\u3061\u5916\u6575\u304b\u3089\u8eab\u3092\u5b88\u308b\u9632\u885b\u8ecd\u306b\u6226\u95d8\u3092\u958b\u59cb\u3059\u308b\u3088\u3046\u306b\u6307\u793a\u3092\u51fa\u3057\u307e\u3059\u3002<\/strong>\u305d\u3057\u3066\u3001\u30ea\u30f3\u30d1\u7bc0\u306b\u79fb\u52d5\u3057\u3066T<\/strong>\u7d30\u80de<\/strong>\u3068\u3044\u3046\u30ea\u30f3\u30d1\u7403\u306b\u3069\u3093\u306a\u6575\u304b\u3092\u4f1d\u3048\u307e\u3059\u3002<\/strong><\/p>\n

\u9632\u885b\u8ecd\u306b\u306f\u69d8\u3005\u306a\u7a2e\u985e\u306e\u653b\u6483\u90e8\u968a\u3001\u3059\u306a\u308f\u3061\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8<\/strong>\u3084\u597d\u9178\u7403<\/strong>\u3001\u597d\u4e2d\u7403<\/strong>\u3001\u30ea\u30f3\u30d1\u7403<\/strong>\u306a\u3069\u306e\u767d\u8840\u7403\uff08\u708e\u75c7\u7d30\u80de\uff09<\/strong>\u304c\u3044\u3066\u3001\u69d8\u3005\u306a\u653b\u6483\u65b9\u6cd5\u3067\u5916\u6575\u304b\u3089\u8eab\u3092\u5b88\u308a\u307e\u3059\u3002<\/p>\n

\u5916\u6575\u306e\u4fb5\u5165\u90e8\u4f4d\u306b\u96c6\u307e\u3063\u3066\u304d\u305f\u3001\u672a\u719f\u6a39\u72b6\u7d30\u80de\u3092\u542b\u3081\u305f\u708e\u75c7\u7d30\u80de\u306f\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3<\/strong>\/<\/strong>\u30b1\u30e2\u30ab\u30a4\u30f3<\/strong>\u3068\u3044\u3046\u514d\u75ab\u3092\u523a\u6fc0\u3059\u308b\u30db\u30eb\u30e2\u30f3\u306e\u3088\u3046\u306a\u3082\u306e\u3092\u5206\u6ccc\u3057\u307e\u3059\u3002\u708e\u75c7\u7d30\u80de\u306f\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\/\u30b1\u30e2\u30ab\u30a4\u30f3\u306b\u3088\u3063\u3066\u4e92\u3044\u3092\u523a\u6fc0\u3057\u5408\u3044\u3001\u3088\u308a\u6d3b\u767a\u306b\u306a\u3063\u3066\u5916\u6575\u3092\u653b\u6483\u3057\u307e\u3059\u3002<\/p>\n

\"\u6b63\u5e38\u306a\u672a\u719f\u6a39\u72b6\u7d30\u80de\"<\/a><\/div>\n

\u3053\u306e\u3088\u3046\u306b\u3001\u672a\u719f\u6a39\u72b6\u7d30\u80de\u306f\u3001\u6226\u95d8\u958b\u59cb\u6642\u306b\u4e00\u756a\u521d\u3081\u306b\u50cd\u304f\u3001\u975e\u5e38\u306b\u6d3b\u52d5\u7684\u306a\u7d30\u80de\u306a\u306e\u3067\u3059\u3002<\/strong><\/p>\n

\uff19\uff0e\u6226\u95d8\u304c\u7d9a\u304f\u3068\u3069\u3046\u306a\u308b\u304b\uff1f<\/h2>\n

\u6226\u95d8\u304c\u8d77\u3053\u308b\u3068\u5371\u967a\u3067\u3059\u3002\u3042\u3061\u3053\u3061\u306b\u7832\u5f3e\u304c\u843d\u3061\u3001\u4e00\u822c\u5e02\u6c11\u3082\u5dfb\u304d\u6dfb\u3048\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3088\u3063\u3066\u3001\u901a\u5e38\u306f\u5916\u6575\u3092\u3084\u3063\u3064\u3051\u308c\u3070\u6226\u3044\u306f\u7d42\u4e86\u3057\u3001\u5e73\u548c\u3092\u53d6\u308a\u623b\u3059\u3088\u3046\u306b\u3067\u304d\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u708e\u75c7\u7d30\u80de\u306f\u5916\u6575\u3092\u3084\u3063\u3064\u3051\u7d42\u3048\u308c\u3070\u6c88\u9759\u5316\u3059\u308b\u3053\u3068\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n

\u3057\u304b\u3057\u3001\u305f\u3060\u3067\u3055\u3048\u5c11\u3057\u306e\u523a\u6fc0\u3067\u6d3b\u767a\u306b\u306a\u308b\u6027\u8cea\u3092\u6301\u3063\u3066\u3044\u308b\u672a\u719f\u6a39\u72b6\u7d30\u80de\u304c\u304c\u3093\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u305f\u5834\u5408\uff08\uff1d<\/strong>LCH<\/strong>\u7d30\u80de\u3067\u3042\u308b\u5834\u5408\uff09<\/strong>\u306f\u3069\u3046\u306a\u308b\u3067\u3057\u3087\u3046\uff1f<\/p>\n

LCH\u7d30\u80de\u306f\u3001\u3088\u308a\u305f\u304f\u3055\u3093\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3<\/strong>\/<\/strong>\u30b1\u30e2\u30ab\u30a4\u30f3\u3092\u51fa\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u81ea\u5206\u3092\u523a\u6fc0\u3057\u7d9a\u3051\u3001\u3057\u3076\u3068\u304f\u751f\u304d\u6b8b\u308a\u3001\u306a\u304b\u306a\u304b\u6226\u3044\u3092\u6b62\u3081\u307e\u305b\u3093\u3002<\/strong>\u307e\u305f\u3001\u30ea\u30f3\u30d1\u7bc0\u306b\u884c\u3063\u3066T\u7d30\u80de\u306b\u60c5\u5831\u3092\u4f1d\u3048\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u6020\u308a\u3001\u5c40\u6240\u306b\u7559\u307e\u308a\u6226\u3044\u3092\u7d9a\u3051\u307e\u3059\u3002<\/strong>\u305d\u306e\u7d50\u679c\u3001\u6226\u95d8\u304c\u5ef6\u3005\u3068\u7d9a\u304d\u3001\u6226\u5834\u306f\u8352\u308c\u679c\u3066\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u3001\u9aa8\u3067\u3053\u306e\u3088\u3046\u306a\u3053\u3068\u304c\u8d77\u3053\u308c\u3070\u9aa8\u306f\u6eb6\u3051\u3066\u3057\u307e\u3046\u3057\u3001\u76ae\u819a\u3067\u8d77\u3053\u308c\u3070\u76ae\u819a\u708e\u3084\u6f70\u760d\u304c\u3067\u304d\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/strong><\/p>\n

\u304c\u3093\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u5165\u3063\u305f\u306e\u304c\u3001\u514d\u75ab\u53cd\u5fdc\u306e\u4e00\u756a\u521d\u3081\u306b\u50cd\u304f\u3001\u6d3b\u52d5\u7684\u306a\u672a\u719f\u6a39\u72b6\u7d30\u80de\u3067\u3042\u3063\u305f\u305f\u3081\u306b\u3001\u904e\u5270\u306a\u514d\u75ab\u53cd\u5fdc\u304c\u5c40\u6240\u3067\u7d9a\u3044\u3066\u3001\u75c7\u72b6\u304c\u51fa\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<\/strong><\/p>\n

\"\u300c\u304c\u3093\u300d\u907a\u4f1d\u5b50\u3092\u6301\u3064\u672a\u719f\u6a39\u72b6\u7d30\u80de\uff08\uff1dLCH\u7d30\u80de\uff09\"<\/a><\/div>\n

LCH\u306e\u6b63\u4f53\u306b\u3064\u3044\u3066\u3001\u3054\u7406\u89e3\u3044\u305f\u3060\u3051\u305f\u3067\u3057\u3087\u3046\u304b\uff1f\u3000\u6b21\u56de<\/a>\u306f\u3001\u3067\u306f\u3069\u306e\u3088\u3046\u306b\u3057\u3066LCH\u3092\u6cbb\u7642\u3059\u308c\u3070\u3044\u3044\u306e\u304b\u3001\u3059\u306a\u308f\u3061\u3001\u6226\u95d8\u3092\u7d42\u308f\u3089\u305b\u308c\u3070\u3044\u3044\u306e\u304b\uff1f\u306b\u3064\u3044\u3066\u8003\u3048\u3066\u307f\u307e\u3057\u3087\u3046\u3002To be continued! \u4e5e\u3046\u3054\u671f\u5f85\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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LCH\u306b\u7acb\u3061\u5411\u304b\u3046\u305f\u3081\u306b\u306f\u3001LCH\u3068\u306f\u4e00\u4f53\u4f55\u306a\u306e\u304b\u3001\u305d\u306e\u6b63\u4f53\u3092\u63a2\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

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