{"id":92199,"date":"2019-09-05T07:30:43","date_gmt":"2019-09-04T22:30:43","guid":{"rendered":"https:\/\/www.ishamachi.com\/?p=92199"},"modified":"2019-08-20T09:48:48","modified_gmt":"2019-08-20T00:48:48","slug":"lch%e3%81%ae%e4%bb%b2%e9%96%93%e3%81%ae%e7%97%85%e6%b0%97%e3%80%8c%e7%b5%84%e7%b9%94%e7%90%83%e7%97%87%e3%80%8d%e3%81%ab%e3%81%af%e3%81%a9%e3%82%93%e3%81%aa%e3%82%82%e3%81%ae%e3%81%8c%e3%81%82","status":"publish","type":"post","link":"https:\/\/www.ishamachi.com\/?p=92199","title":{"rendered":"LCH\u306e\u4ef2\u9593\u306e\u75c5\u6c17\u300c\u7d44\u7e54\u7403\u75c7\u300d\u306b\u306f\u3069\u3093\u306a\u3082\u306e\u304c\u3042\u308b\uff1f"},"content":{"rendered":"<p>\u524d\u56de\u307e\u3067\u306f\u3001\u30e9\u30f3\u30b2\u30eb\u30cf\u30f3\u30b9\u7d30\u80de\u7d44\u7e54\u7403\u75c7\uff08LCH\uff09\u306b\u3064\u3044\u3066\u89e3\u8aac\u3092\u884c\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u4eca\u56de\u306f\u3001LCH\u306e\u4ef2\u9593\u306e\u75c5\u6c17\u3067\u3042\u308b<strong>\u82e5\u5e74\u6027\u9ec4\u8272\u8089\u82bd\u816b\u75c7\uff08JXG\uff09\u3001\u30ed\u30fc\u30b6\u30a4\u30fb\u30c9\u30eb\u30d5\u30de\u30f3\u75c5(Rosai-Dorfman disease, RDD)\u3001\u30a8\u30eb\u30c9\u30cf\u30a4\u30e0\u30fb\u30c1\u30a7\u30b9\u30bf\u30fc\u75c5\uff08Erdheim-Chester disease, ECD\uff09<\/strong>\u306b\u3064\u3044\u3066\u7d39\u4ecb\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p>LCH\u3082\u542b\u3081\u3066\u3053\u308c\u3089\u306f\u5168\u3066<strong>\u300c\u7d44\u7e54\u7403\u75c7\u300d\uff08Histiocytosis\uff09<\/strong>\u3068\u3044\u3046\u75be\u60a3\u3067\u3001\u8840\u6db2\u306e\u4e2d\u3067\u3082\u7d44\u7e54\u7403\u3068\u547c\u3070\u308c\u308b\u3001<strong>\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8<\/strong>\u3084<strong>\u6a39\u72b6\u7d30\u80de<\/strong>\u3001<strong>\u5358\u7403<\/strong>\u7531\u6765\u306e\u7d30\u80de\u304c\u3001\u4f53\u3058\u3085\u3046\u306e\u69d8\u3005\u306a\u81d3\u5668\u3067\u5897\u3048\u3066\u3057\u307e\u3046\u75c5\u6c17\u3067\u3059\u3002<\/p>\n<div style=\"max-width: 400px; margin: 1rem; text-align: center;\"><a href=\"https:\/\/www.ishamachi.com\/wp-content\/uploads\/2019\/08\/Histiocytosis-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-92258\" src=\"https:\/\/www.ishamachi.com\/wp-content\/uploads\/2019\/08\/Histiocytosis-1.jpg\" alt=\"\u7d44\u7e54\u7403\u75c7\u3068\u306f\" width=\"800\" height=\"1131\" \/><\/a><\/div>\n<p>\u6614\u306f<strong>\u300cLCH\u300d<\/strong>\u3068<strong>\u300cLCH\u4ee5\u5916\u300d<\/strong>\u3068\u306b\u5206\u3051\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u6642\u4ee3\u306f\u9032\u307f\u3001\u8840\u6db2\u691c\u67fb\u3084\u753b\u50cf\u8a55\u4fa1\u3001\u75c5\u7406\u691c\u67fb\u306a\u3069\u306b\u3088\u308b\u8a3a\u65ad\u6280\u8853\u306e\u767a\u5c55\u306b\u52a0\u3048\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u7814\u7a76\u306e\u9032\u6b69\u306b\u3088\u3063\u3066\u3001\u4eca\u3084100\u3082\u306e\u4ef2\u9593\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u5927\u304d\u304f\u306f\uff15\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u3051\u3089\u308c\u308b\u306e\u3067\u3059\u304c\u3001LCH\u3068\u4eca\u56de\u89e3\u8aac\u3059\u308bECD\u3001RDD\u3001\u305d\u3057\u3066\u5168\u8eab\u6027\u306eJXG\u306b\u306f\u3001\u306a\u3093\u3068\uff08\uff01\uff09\u5168\u3066<strong>MAPK\u7d4c\u8def\u306e\u907a\u4f1d\u5b50\u5909\u7570<\/strong>\uff08\u68ee\u672c\u54f2\u5148\u751f\u306e\u300c<a href=\"https:\/\/www.ishamachi.com\/?p=90941\">\u300e\u6575\u3092\u77e5\u308a\u3001\u5df1\u3092\u77e5\u308c\u3070\u3001\u767e\u6226\u5371\u3046\u304b\u3089\u305a\u300f\u30e9\u30f3\u30b2\u30eb\u30cf\u30f3\u30b9\u7d30\u80de\u7d44\u7e54\u7403\u75c7\uff08LCH\uff09\u306e\u6b63\u4f53\u306f\u4f55\uff1f<\/a>\u300d\u3092\u898b\u3066\u306d\uff09\u304c\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>\u3069\u308c\u3082\u3068\u3066\u3082\u307e\u308c\u306a\u75c5\u6c17\u3067\u3001\u308f\u304b\u3089\u306a\u3044\u3053\u3068\u304c\u307e\u3060\u307e\u3060\u305f\u304f\u3055\u3093\u3042\u308a\u307e\u3059\u304c\u3001\u6700\u8fd1\u306e\u8a71\u984c\u3092\u7d39\u4ecb\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<h2>\uff11\uff0e\u82e5\u5e74\u6027\u9ec4\u8272\u8089\u82bd\u816b\u75c7\uff08Juvenile Xanthogranuloma; JXG\uff09<\/h2>\n<div style=\"max-width: 400px; margin: 1rem; text-align: center;\"><a href=\"https:\/\/www.ishamachi.com\/wp-content\/uploads\/2019\/08\/Histiocytosis-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-92256\" src=\"https:\/\/www.ishamachi.com\/wp-content\/uploads\/2019\/08\/Histiocytosis-2.jpg\" alt=\"\u82e5\u5e74\u6027\u9ec4\u8272\u8089\u82bd\u816b\uff08JXG\uff09\u306e\u76ae\u75b9\" width=\"800\" height=\"1352\" \/><\/a><\/div>\n<p><strong>\u300c\u82e5\u5e74\u6027\u300d\u2212\u300c\u9ec4\u8272\u300d\u2212\u300c\u8089\u82bd\u816b\u75c7\u300d<\/strong>\uff08JXG\uff09\u306f\u540d\u524d\u306e\u901a\u308a\u3001<strong>\u300c\u5b50\u3069\u3082\u306b\u591a\u3044\u300d\u3001\u300c\u9ec4\u8272\u306e\u8089\u82bd\u816b\uff08\u3067\u304d\u3082\u306e\uff09\u300d<\/strong>\u304c\u76ae\u819a\u3084\u4f53\u306e\u4e2d\u306b\u3067\u304d\u308b\u75c5\u6c17\u3067\u3059\u3002<\/p>\n<p>JXG\u306e\u3053\u3069\u3082\u305f\u3061\u306e\u5927\u534a\u306f\u3001\u9ec4\u8272\u304b\u3089\u8910\u8272\u306e\u7d50\u7bc0\uff08\u3077\u304f\u3063\u3068\u98db\u3073\u51fa\u305f\u767a\u75b9\uff09\u304c\u8d64\u3061\u3083\u3093\u306e\u3053\u308d\u306b\u3067\u3066\u304d\u3066\u30011-2\u6b73\u307e\u3067\u306f\u6570\u304c\u5897\u3048\u305f\u308a\u4e00\u3064\u3072\u3068\u3064\u304c\u5927\u304d\u304f\u306a\u3063\u305f\u308a\u3057\u307e\u3059\u3002\u7d50\u7bc0\u306f1\u500b\u306e\u3053\u3068\u3082\u3042\u308c\u3070\u300150\u500b\u4ee5\u4e0a\u306e\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u3068\u304d\u306b\u306f\u4e00\u3064\u304c2\u339d\u3092\u8d85\u3048\u3066\u5927\u304d\u304f\u306a\u308a\u3001\u4e2d\u592e\u304c\u3058\u304f\u3058\u304f\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u305f\u3044\u3066\u3044\u306f\u3001\u4f55\u3082\u3057\u306a\u304f\u3066\u3082\u6b21\u7b2c\u306b\u3057\u307c\u3093\u3067\u5e73\u5766\u306b\u306a\u3063\u3066\u3044\u304d\u3001\u8272\u3082\u6de1\u304f\u306a\u3063\u3066\u3001<strong>5\u6b73\u9803\u307e\u3067\u306b\u306f\u3069\u308c\u3082\u304d\u308c\u3044\u306b\u6d88\u3048\u3066\u3044\u304d\u307e\u3059<\/strong>\uff08\u5927\u304d\u304f\u3066\u3068\u3066\u3082\u56f0\u308b\u3082\u306e\u306f\u3001\u5207\u9664\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\uff09\u3002\u76ae\u819a\u4ee5\u5916\u306b\u75c7\u72b6\u304c\u306a\u304f\u3066\u3001\u81ea\u7136\u306b\u6d88\u3048\u3066\u3044\u304f\u30bf\u30a4\u30d7\u306eJXG\u306f\u3001\u85ac\u306b\u3088\u308b\u6cbb\u7642\u3092\u5fc5\u8981\u3068\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u306e\u3067\u5fc3\u914d\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u305d\u306e\u4e00\u65b9\u3067\u3001\u76ae\u819a\u3060\u3051\u3067\u306a\u304f<strong>\u4f53\u306e\u3042\u3061\u3053\u3061\u306e\u81d3\u5668\u306b\u7d50\u7bc0\uff08\u8089\u82bd\u816b\uff09\u304c\u3067\u304d\u308b<\/strong>\u3053\u3068\u304c\u7a00\u306b\u3042\u308a\u307e\u3059\uff08\u3053\u306e\u3088\u3046\u306a\u30bf\u30a4\u30d7\u3092<strong>\u5168\u8eab\u6027\u9ec4\u8272\u8089\u82bd\u816b\u75c7<\/strong>\u3068\u547c\u3073\u307e\u3059\uff09\u3002\u5168\u8eab\u6027\u9ec4\u8272\u8089\u82bd\u816b\u75c7\u306f\u521d\u3081\u3066\u306e\u304a\u8a95\u751f\u65e5\u3092\u8fce\u3048\u308b\u524d\u306e\u3053\u3069\u3082\uff08<strong>1\u6b73\u672a\u6e80<\/strong>\uff09\u306b\u591a\u304f\u3001\u65b0\u751f\u5150\u306b\u3082\u8d77\u3053\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u751f\u307e\u308c\u305f\u3066\u306e\u65b0\u751f\u5150\u3067\u306f\u3001\u7d2b\u8272\u306e\u5c11\u3057\u76db\u308a\u4e0a\u304c\u3063\u305f\u4e18\u75b9\uff08\u307e\u308b\u3067<strong>\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc\u30de\u30d5\u30a3\u30f3<\/strong>\uff01\uff09\u304c\u76ae\u819a\u306b\u305f\u304f\u3055\u3093\u3067\u304d\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u3068\u304d\u306b\u306f\u76ae\u819a\u306b\u306f\u4f55\u3082\u75c7\u72b6\u304c\u306a\u304f\u3001<strong>\u8133\u3084\u5185\u81d3\u306b\u3060\u3051<\/strong>\u3001\u3068\u3044\u3046\u4f8b\u3082\u3042\u308a\u307e\u3059\u3002\u809d\u81d3\u306e\u4e2d\u306b\u7d50\u7bc0\u304c\u3067\u304d\u308b\u3068\u809d\u81d3\u304c\u816b\u308c\u305f\u308a\u3001\u80ba\u306b\u3067\u304d\u308b\u3068\u547c\u5438\u304c\u3057\u3093\u3069\u304b\u3063\u305f\u308a\u3001\u76ee\u306b\u3067\u304d\u308b\u3068\u7247\u76ee\u3060\u3051\u304c\u8d64\u304f\u306a\u3063\u3066\u8996\u529b\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u305f\u308a\u3001\u982d\u306e\u4e2d\u306b\u3067\u304d\u308b\u3068\u75d9\u6523\u3057\u305f\u308a\u3001\u3068\u3044\u308d\u3044\u308d\u306a\u75c7\u72b6\u3092\u8d77\u3053\u3057\u307e\u3059\u3002\u76ae\u819a\u306e\u307f\u306eJXG\u3068\u9055\u3063\u3066\u3001\u5168\u8eab\u6027\u9ec4\u8272\u8089\u82bd\u816b\u75c7\u306b\u5bfe\u3057\u3066\u306f<strong>\u30b9\u30c6\u30ed\u30a4\u30c9\u3084\u6297\u304c\u3093\u5264\u3092\u4f7f\u3063\u305f\u6cbb\u7642<\/strong>\uff08LCH\u306b\u884c\u3046\u6cbb\u7642\u3068\u4f3c\u305f\u6cbb\u7642\uff09\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>JXG\u306f\u76ae\u819a\u306e\u767a\u75b9\u304c\u8a3a\u65ad\u306e\u304d\u3063\u304b\u3051\u306b\u306a\u308b\u3053\u3068\u304c\u591a\u3044\u306e\u3067\u3001\u3042\u305b\u3082\u3084\u6c34\u3044\u307c\u304b\u306a\uff1f\u3068\u3001\u307e\u305a\u306f\u76ae\u819a\u79d1\u306b\u884c\u304f\u3053\u3068\u304c\u591a\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u76ae\u819a\u79d1\u306e\u5148\u751f\u306b\u300c\u9ec4\u8272\u8089\u82bd\u816b\u304b\u3082\u300d\u3068\u8a00\u308f\u308c\u305f\u3089\u3001<strong>\u5c0f\u5150\u79d1\u306e\u5148\u751f\u306e\u8a3a\u5bdf\u3082\u53d7\u3051\u3066\u3044\u305f\u3060\u304f\u3068\u5b89\u5fc3\u3067\u3059\u3002<\/strong><\/p>\n<h2>\uff12\uff0e\u30ed\u30fc\u30b6\u30a4\u30fb\u30c9\u30eb\u30d5\u30de\u30f3\u75c5\uff08Rosai-Dorfman disease; RDD\uff09<\/h2>\n<p>RDD\u306f\u30011969\u5e74\u306bJuan <u>Rosai<\/u>\u3055\u3093\u3068Ronald <u>Dorfman<\/u>\u3055\u3093\u304c\u767a\u898b\u3057\u305f\u75c5\u6c17\u3067\u3059\uff08\u73cd\u3057\u3044\u75c5\u6c17\u306e\u540d\u524d\u306f\u3001\u306f\u3058\u3081\u306b\u898b\u3064\u3051\u305f\u4eba\u306e\u540d\u524d\u304c\u3064\u304f\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u306d\uff09\u300220\u6b73\u524d\u5f8c\u306e\u5927\u4eba\u306b\u8d77\u3053\u308b\u3053\u3068\u304c\u591a\u3044\u75c5\u6c17\u3067\u3001<strong>\u300c\u9996\u306e\u30ea\u30f3\u30d1\u7bc0\u304c\u816b\u308c\u305f\uff1d\u9996\u306b\u30b4\u30ea\u30b4\u30ea\u3057\u305f\u3067\u304d\u3082\u306e\u3092\u89e6\u308c\u308b\u300d<\/strong>\u3068\u3044\u3063\u3066\u53d7\u8a3a\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u304f\u307f\u3089\u308c\u307e\u3059\u3002\u305d\u308c\u3060\u3051\u3067\u306a\u304f\u3001\u76ae\u819a\u306e\u767a\u75b9\u3084\u3001\u9aa8\u3001\u809d\u81d3\u3001\u813e\u81d3\u3001\u5fc3\u81d3\u3001\u80ba\u3001\u814e\u81d3\u3001\u982d\u306e\u4e2d\u306a\u3069<strong>\u4f53\u306e\u3055\u307e\u3056\u307e\u306a\u5834\u6240\u306b\u3067\u304d\u3082\u306e\u3092\u4f5c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/strong><\/p>\n<p>\u307e\u305f\u3001RDD\u306b\u7279\u5fb4\u7684\u306a\u6240\u898b\u3068\u3057\u3066\u3001<strong>\u81ea\u5df1\u514d\u75ab\u6027\u75be\u60a3<\/strong>\u3068\u547c\u3070\u308c\u308b\u81ea\u5206\u306e\u4f53\u3092\u6575\u3068\u601d\u3063\u3066\u653b\u6483\u3057\u3066\u58ca\u3057\u3066\u3057\u307e\u3046\u75c5\u6c17\u3084<strong>\u307b\u304b\u306e\u304c\u3093<\/strong>\u304c\u4e00\u7dd2\u306b\u51fa\u3066\u304f\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u3088\u3046\u306b\u3001RDD\u306e\u75c7\u72b6\u306f<strong>\u75c7\u4f8b\u3054\u3068\u306b\u3060\u3044\u3076\u7570\u306a\u308a\u3001\u6cbb\u7642\u6cd5\u3082\u591a\u5c90\u306b\u308f\u305f\u308a\u307e\u3059\u3002<\/strong>\u81ea\u7136\u306b\u6cbb\u3063\u3066\u3057\u307e\u3046\u3082\u306e\u304b\u3089\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u3001\u66f4\u306b\u306f\u6297\u304c\u3093\u5264\u3084\u5206\u5b50\u6a19\u7684\u85ac\u306a\u3069\u3092\u7528\u3044\u305f\u6cbb\u7642\u3001\u624b\u8853\u3084\u653e\u5c04\u7dda\u7167\u5c04\u304c\u5fc5\u8981\u3068\u306a\u308b\u3082\u306e\u307e\u3067\u3055\u307e\u3056\u307e\u3067\u3001\u73fe\u6642\u70b9\u3067\u306f\u5b9a\u307e\u3063\u305f\u3082\u306e\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u6210\u4eba\u306e\u5834\u5408\u306f<strong>\u8840\u6db2\u5185\u79d1<\/strong>\u3001\u3053\u3069\u3082\u3067\u3042\u308c\u3070<strong>\u5c0f\u5150\u8840\u6db2\u816b\u760d\u306e\u5c02\u9580\u533b<\/strong>\u3068\u3001\u75c7\u4f8b\u6bce\u306b\u9069\u3057\u305f\u6cbb\u7642\u3092\u691c\u8a0e\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<h2>\uff13\uff0e\u30a8\u30eb\u30c9\u30cf\u30a4\u30e0\u30fb\u30c1\u30a7\u30b9\u30bf\u30fc\u75c5\uff08Erdheim-Chester disease; ECD\uff09<\/h2>\n<p>ECD\u306f\u30011930\u5e74\u306bJacob <u>Erdheim<\/u>\u3055\u3093\u3068William <u>Chester<\/u>\u3055\u3093\u304c\u767a\u898b\u3057\u305f\u75c5\u6c17\u3067\u3059\uff08\u3084\u3063\u3071\u308a\u73cd\u3057\u3044\u75c5\u6c17\u306e\u540d\u524d\u306f\u3001\u306f\u3058\u3081\u306b\u898b\u3064\u3051\u305f\u4eba\u306e\u540d\u524d\u304c\u3064\u304f\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u306d\uff09\u3002<\/p>\n<p><strong>50-70<\/strong><strong>\u624d\u524d\u5f8c\u306e\u5927\u4eba\u306b\u591a\u3044\u75c5\u6c17\u3067\u3001\u5c0f\u5150\u306e\u5831\u544a\u306f\u3068\u3066\u3082\u7a00<\/strong>\u3067\u3059\u3002LCH\u306e\u75c5\u5909\u90e8\u4f4d\u3068\u4f3c\u3066\u304a\u308a\u3001\u9aa8\u306b\u75c5\u6c17\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u591a\u304f\u307f\u3089\u308c\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u3042\u3061\u3053\u3061\u306e\u9aa8\u304c\u6eb6\u3051\u308bLCH\u3068\u306f\u69d8\u5b50\u304c\u5927\u304d\u304f\u7570\u306a\u308a\u3001<strong>\u5de6\u53f3\u5bfe\u79f0\u306b\u624b\u8db3\u306e\u9aa8\u304c\u7570\u5e38\u306b\u786c\u304f\u306a\u3063\u3066\u3057\u307e\u3046\u6240\u898b\uff08\u9aa8\u786c\u5316\uff09<\/strong>\u3092\u8a8d\u3081\u308b\u306e\u304cECD\u306e\u7279\u5fb4\u3067\u3059\u3002<\/p>\n<p><strong>\u9aa8\u306e\u75db\u307f<\/strong>\u306e\u307b\u304b\u3001<strong>\u8133\u306e\u4e2d\u3084\u81d3\u5668<\/strong>\u306b\u75c5\u5909\u3092\u304d\u305f\u3057\u3066\u3001\u3055\u307e\u3056\u307e\u306a\u75c7\u72b6\u3092\u5448\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u80f8\u90e8\u3084\u5f8c\u8179\u819c\u3068\u3044\u3046\u4f4d\u7f6e\u306b\u5b58\u5728\u3059\u308b\u5927\u8840\u7ba1\u3084\u814e\u81d3\u306a\u3069\u304c\u3001\u307e\u308b\u3067\u5375\u306e\u6bbb\u306e\u3088\u3046\u306b\u5e83\u304f\u56fa\u304f\u53d6\u308a\u56f2\u307e\u308c\u3066\u3057\u307e\u3044\u3001\u81d3\u5668\u306e\u969c\u5bb3\u3078\u3068\u9032\u884c\u3057\u307e\u3059\u3002\u307e\u305f\u3001ECD\u3067\u306f\u3001LCH\u306e\u4e00\u90e8\u306e\u75c7\u4f8b\u3067\u307f\u3089\u308c\u308b<strong>\u5c3f\u5d29\u75c7<\/strong>\uff08\u304a\u3057\u3063\u3053\u304c\u3044\u3063\u3071\u3044\u3067\u3066\u3057\u307e\u3046\u75c5\u6c17\uff09\u304c\u7d0420%\u306e\u60a3\u8005\u3055\u3093\u306b\u8d77\u3053\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u6cbb\u7642\u3068\u3057\u3066\u306f\u3001\u5316\u5b66\u7642\u6cd5\u3092\u306f\u3058\u3081\u3001\u7d44\u7e54\u7403\u306e\u6d3b\u52d5\u3084\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u6291\u3048\u308b\u3055\u307e\u3056\u307e\u306a\u85ac\u5264\u304c\u8a66\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002ECD\u306fLCH\u3068\u540c\u69d8\u306b\u3001\u534a\u6570\u4ee5\u4e0a\u306e\u75c7\u4f8b\u306b\u304a\u3044\u3066BRAF\u907a\u4f1d\u5b50\u5909\u7570\u304c\u8a8d\u3081\u3089\u308c\u308b\u3053\u3068\u304b\u3089\u3001\u6700\u8fd1\u3067\u306fBRAF\/MEK\u963b\u5bb3\u5264\u3068\u3044\u3046\u5206\u5b50\u6a19\u7684\u85ac\u306e\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u304a\u308a\u3001\u6d77\u5916\u3067\u6cbb\u9a13\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u85ac\u3092\u4e2d\u6b62\u3059\u308b\u3068\u591a\u304f\u306e\u75c7\u4f8b\u306f\u3059\u3050\u306b\u518d\u767a\u3057\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u308f\u304b\u308a\u3001\u9069\u5207\u306a\u6cbb\u7642\u6cd5\u306e\u767b\u5834\u306b\u306f\u307e\u3060\u6642\u9593\u304c\u304b\u304b\u308a\u305d\u3046\u3067\u3059\u3002<\/p>\n<p>ECD\u3067\u306f<strong>\u9aa8\u306e\u75c7\u72b6\uff08\u8db3\u3001\u8155\u3001\u8170\u306a\u3069\u306e\u75db\u307f\u3084\u3057\u3073\u308c\uff09<\/strong>\u304c\u591a\u304f\u3001\u307e\u305a\u306f\u6574\u5f62\u5916\u79d1\u306b\u304b\u304b\u308b\u3053\u3068\u304c\u591a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u307e\u305f\u5168\u8eab\u306b\u75c5\u6c17\u304c\u3067\u304d\u308b\u306e\u3067\u3001\u3055\u307e\u3056\u307e\u306a\u8a3a\u7642\u79d1\u3092\u53d7\u8a3a\u3055\u308c\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u3067\u3082\u3001ECD\u3068\u8a3a\u65ad\u3055\u308c\u305f\u5834\u5408\u306b\u306f\u3001\u5927\u4eba\u306e\u5834\u5408\u306f<strong>\u8840\u6db2\u5185\u79d1<\/strong>\u3001\u3053\u3069\u3082\u306e\u5834\u5408\u306f<strong>\u5c0f\u5150\u8840\u6db2\u816b\u760d\u5c02\u9580\u533b<\/strong>\u306b\u3088\u308b\u8a3a\u7642\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<h2>\uff14\uff0e\u60aa\u6027\u7d44\u7e54\u7403\u75c7<\/h2>\n<p>\u3068\u3066\u3082\u7a00\u306a\u75c5\u614b\u3067\u3001\u304c\u3093\u5316\u3057\u305f\u7d44\u7e54\u7403\u306b\u3088\u308b<strong>\u60aa\u6027\u5ea6\u306e\u9ad8\u3044\u8089\u816b<\/strong>\u3084<strong>\u304c\u3093<\/strong>\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u7d44\u7e54\u7403\u8089\u816b\u306f\u3001\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306a\u3069\u306e\u5225\u306e\u8840\u6db2\u304c\u3093\u306b\u95a2\u9023\u3057\u3066\u751f\u305a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h2>\uff15\uff0e\u8840\u7403\u8caa\u98df\u75c7\u5019\u7fa4<\/h2>\n<p>\u6d3b\u767a\u306b\u306a\u3063\u305f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304c\u7570\u5e38\u306b\u5897\u3048\u3066\u3001\u6b63\u5e38\u306a\u8840\u6db2\u7d30\u80de\u3092\u7d30\u80de\u5185\u306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