{"id":92213,"date":"2019-08-22T07:30:27","date_gmt":"2019-08-21T22:30:27","guid":{"rendered":"https:\/\/www.ishamachi.com\/?p=92213"},"modified":"2019-08-22T17:03:36","modified_gmt":"2019-08-22T08:03:36","slug":"%e3%80%8c%e4%b9%8b%e3%82%92%e7%9f%a5%e3%82%8b%e3%82%82%e3%81%ae%e3%81%af%e5%8b%9d%e3%81%a1%e3%80%81%e7%9f%a5%e3%82%89%e3%81%96%e3%82%8b%e8%80%85%e3%81%af%e5%8b%9d%e3%81%9f%e3%81%9a%e3%80%8d%e3%83%a9","status":"publish","type":"post","link":"https:\/\/www.ishamachi.com\/?p=92213","title":{"rendered":"\u300c\u4e4b\u3092\u77e5\u308b\u3082\u306e\u306f\u52dd\u3061\u3001\u77e5\u3089\u3056\u308b\u8005\u306f\u52dd\u305f\u305a\u300d\u30e9\u30f3\u30b2\u30eb\u30cf\u30f3\u30b9\u7d30\u80de\u7d44\u7e54\u7403\u75c7\uff08LCH\uff09\u306e\u6cbb\u7642\uff1a\u5b9f\u6226\u7de8"},"content":{"rendered":"<h2>\uff11\uff0eLCH\u306f\u708e\u75c7\u6027\u9aa8\u9ac4\u816b\u760d<\/h2>\n<p>\u300c<a 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href=\"https:\/\/www.ishamachi.com\/?p=92083\">\u6210\u4eba<\/a>\u3067\u3088\u304f\u307f\u3089\u308c\u308b<strong>\u80ba\u5358\u72ec\u306e<\/strong><strong>LCH<\/strong>\u306b\u3064\u3044\u3066\u306f\u3001\u547c\u5438\u5668\u5185\u79d1\u306e\u5148\u751f\u65b9\u306f\u3001\u307b\u3068\u3093\u3069\u6cbb\u7642\u305b\u305a\u9759\u89b3\u3055\u308c\u307e\u3059\u3002LCH\u306b\u3088\u3063\u3066\u80ba\u306f\u7834\u58ca\u3055\u308c\u80ba\u56a2\u80de\u306b\u306a\u308a\u307e\u3059\u3002\u80ba\u56a2\u80de\u3068\u3044\u3046\u72b6\u614b\u307e\u3067\u9032\u5c55\u3057\u3066\u3057\u307e\u3063\u3066\u3044\u308b\u5834\u5408\u306b\u306f\u3001\u6297\u816b\u760d\u85ac\u3092\u4f7f\u3063\u3066\u3082\u526f\u4f5c\u7528\u304c\u51fa\u308b\u3060\u3051\u3067\u6539\u5584\u306f\u3057\u306a\u3044\u306e\u3067\u3001\u7a4d\u6975\u7684\u306b\u6cbb\u7642\u3092\u3055\u308c\u306a\u3044\u306e\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u80ba\u56a2\u80de\u306b\u81f3\u308b\u524d\u306e\u65e9\u671f\u306b\u6cbb\u7642\u3092\u958b\u59cb\u3059\u308b\u3068\u52b9\u679c\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3057\u3001\u80ba\u56a2\u80de\u306b\u306a\u3063\u3066\u3044\u308b\u90e8\u5206\u304c\u3042\u3063\u3066\u3082\u6b8b\u3063\u3066\u3044\u308b\u6b63\u5e38\u306a\u80ba\u3092\u60aa\u5316\u3055\u305b\u306a\u3044\u52b9\u679c\u306f\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u80ba\u5358\u72ec\u3068\u601d\u3063\u3066\u3044\u305f\u3089\u591a\u81d3\u5668\u578b\u306b\u9032\u5c55\u3057\u305f\u3068\u3044\u3046\u3088\u3046\u306a\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u80ba\u5358\u72ec\u306eLCH\u3092\u6297\u816b\u760d\u85ac\u306b\u3088\u3063\u3066\u6cbb\u7642\u3059\u308b\u304b\u3069\u3046\u304b\u306f\u3001\u8b70\u8ad6\u3059\u3079\u304d\u8ab2\u984c\u3067\u3059\u3002<\/p>\n<h2>\uff13\uff0e\u6297\u816b\u760d\u3068\u6297\u708e\u75c7\u6cbb\u7642<\/h2>\n<div style=\"max-width: 400px; margin: 1rem; text-align: center;\"><a href=\"https:\/\/www.ishamachi.com\/wp-content\/uploads\/2019\/08\/LCH-treatment-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-92252\" src=\"https:\/\/www.ishamachi.com\/wp-content\/uploads\/2019\/08\/LCH-treatment-1.jpg\" alt=\"LCH\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u308b\u85ac\uff08\u4e00\u4f8b\uff09\" width=\"1000\" height=\"1496\" \/><\/a><\/div>\n<p>\u307e\u305a\u7b2c\u4e00\u306b\u6ce8\u610f\u3057\u3066\u3044\u305f\u3060\u304d\u305f\u3044\u306e\u306f\u3001\u73fe\u5728\u3001<strong>LCH\u306b\u4fdd\u967a\u9069\u5fdc\u306b\u306a\u3063\u3066\u3044\u308b\u85ac\u306f\u3001\u5f8c\u8ff0\u3059\u308b\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3\u3057\u304b\u306a\u3044<\/strong>\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u65e5\u672c\u3067LCH\u306b\u5bfe\u3057\u3066\u5e45\u5e83\u304f\u4f7f\u308f\u308c\u3066\u3044\u308b\u85ac\u306f\u3001\u307b\u3068\u3093\u3069\u304c<strong>\u4fdd\u967a\u9069\u5fdc\u5916\u4f7f\u7528<\/strong>\u3067\u3059\u3002<\/p>\n<p>\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3\u306f\u6d77\u5916\u3067\u627f\u8a8d\u3055\u308c\u3066\u3044\u305f\u306e\u3067\u3001<strong>\u516c\u77e5\u7533\u8acb<\/strong>\u3068\u3044\u3046\u65b9\u6cd5\u306b\u3088\u3063\u3066\u3001\u56fd\u5185\u3067\u6cbb\u9a13\u3092\u305b\u305a\u306b\u4fdd\u967a\u9069\u5fdc\u304c\u53d6\u308c\u307e\u3057\u305f\u3002LCH\u304c\u5e0c\u5c11\u75be\u60a3\u3067\u60a3\u8005\u3055\u3093\u304c\u5c11\u306a\u304f\u3001\u304b\u3064\u3001LCH\u306b\u5bfe\u3057\u3066\u4f7f\u308f\u308c\u308b\u591a\u304f\u306e\u85ac\u306f\u767a\u58f2\u3055\u308c\u3066\u304b\u3089\u9577\u5e74\u7d4c\u904e\u3057\u3066\u3044\u308b\u3001\u3059\u306a\u308f\u3061\u85ac\u4fa1\u304c\u5b89\u304f\u5132\u3051\u304c\u5c11\u306a\u3044\u306e\u3067\u3001\u88fd\u85ac\u4f1a\u793e\u306f\u4eca\u66f4\u304a\u91d1\u306e\u304b\u304b\u308b\u6cbb\u9a13\u306a\u3069\u3084\u308a\u307e\u305b\u3093\u3002\u306a\u306e\u3067\u3001\u4fdd\u967a\u9069\u5fdc\u5916\u4f7f\u7528\u3068\u3044\u3046\u3044\u3073\u3064\u306a\u72b6\u614b\u304c\u7d9a\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3055\u3066\u3055\u3066\u3001\u6c17\u3092\u53d6\u308a\u76f4\u3057\u3066LCH\u306e\u6cbb\u7642\u6226\u7565\u306b\u3064\u3044\u3066\u8003\u3048\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>LCH\u7d30\u80de\u306f\u3001\u767d\u8840\u7403\u306e\u4e00\u7a2e\u3067\u3059\u3002\u767d\u8840\u7403\u306f\u3001\u5927\u304d\u304f\u5206\u3051\u308b\u3068\u9aa8\u9ac4\u7cfb\u3068\u30ea\u30f3\u30d1\u7cfb\u306e2\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u3002\u6025\u6027\u767d\u8840\u75c5\u306b\u3082\u9aa8\u9ac4\u7cfb\u306e\u3082\u306e\u3068\u30ea\u30f3\u30d1\u7cfb\u306e\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u3053\u306e2\u3064\u3067\u306f\u3001\u6cbb\u7642\u306b\u4f7f\u308f\u308c\u308b\u6297\u816b\u760d\u85ac\u304c\u304b\u306a\u308a\u9055\u3044\u307e\u3059\u3002\u9aa8\u9ac4\u7cfb\u306e\u767d\u8840\u75c5\u306e\u6cbb\u7642\u3067\u306f\u3001\u30b7\u30bf\u30e9\u30d3\u30f3\u3084\u30a8\u30c8\u30dd\u30b7\u30c9\u3068\u3044\u3046\u85ac\u5264\u304c\u4e3b\u5f79\u3067\u3059\u3002\u4e00\u65b9\u3001\u30ea\u30f3\u30d1\u7cfb\u306e\u767d\u8840\u75c5\u306b\u306f\u526f\u814e\u76ae\u8cea\u30b9\u30c6\u30ed\u30a4\u30c9\uff08\u30d7\u30ec\u30c9\u30cb\u30be\u30ed\u30f3\u306a\u3069\uff09\u3068\u30d3\u30f3\u30ab\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\uff08\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u306a\u3069\uff09\u306a\u3069\u3092\u4e3b\u306b\u4f7f\u3044\u307e\u3059\u3002<\/p>\n<p>LCH\u7d30\u80de<strong>\u306f\u9aa8\u9ac4\u7cfb\u7d30\u80de<\/strong>\u3067\u3059\u3002\u306a\u306e\u3067\u3001LCH\u7d30\u80de\u306b\u5bfe\u3057\u3066\u306f\u3001<strong>\u9aa8\u9ac4\u7cfb\u306b\u5bfe\u3059\u308b\u6297\u816b\u760d\u85ac<\/strong>\u3092\u9078\u3076\u3079\u304d\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u305d\u3057\u3066\u3001LCH\u7d30\u80de\u3092\u53d6\u308a\u5dfb\u304f\u708e\u75c7\u7d30\u80de\u3092\u304a\u3068\u306a\u3057\u304f\u3055\u305b\u308b\u6297\u708e\u75c7\u85ac\u3068\u3057\u3066\u306f\u3001<strong>\u526f\u814e\u76ae\u8cea\u30b9\u30c6\u30ed\u30a4\u30c9<\/strong>\u3084<strong>\u30d3\u30f3\u30ab\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9<\/strong>\u304c\u6709\u52b9\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u30a8\u30c8\u30dd\u30b7\u30c9\u3068\u3044\u3046\u9aa8\u9ac4\u7cfb\u306e\u816b\u760d\u306b\u4f7f\u308f\u308c\u308b\u85ac\u306f\u30011990\u5e74\u4ee3\u307e\u3067LCH\u306e\u6cbb\u7642\u306b\u5e83\u304f\u4f7f\u308f\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u52b9\u679c\u3082\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u30a8\u30c8\u30dd\u30b7\u30c9\u306b\u306f<strong>\u4e8c\u6b21\u6027\u767d\u8840\u75c5<\/strong>\u3068\u3044\u3046\u91cd\u5927\u306a\u526f\u4f5c\u7528\u304c\u3042\u308a\u3001\u30a8\u30c8\u30dd\u30b7\u30c9\u306b\u3088\u308a\u6cbb\u7642\u3092\u53d7\u3051\u305fLCH\u306e\u60a3\u8005\u3055\u3093\u304c\u6025\u6027\u524d\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306b\u306a\u3063\u3066\u3057\u307e\u3063\u305f\u3068\u3044\u3046\u5831\u544a\u304c\u76f8\u6b21\u304e\u307e\u3057\u305f\uff08Kudo K, 1998\uff09\u3002\u4e8c\u6b21\u6027\u767d\u8840\u75c5\u304c\u751f\u3058\u308b\u983b\u5ea6\u306f1\uff05\u307b\u3069\u3068\u9ad8\u304f\u306f\u306a\u3044\u306e\u3067\u3059\u304c\u3001\u3053\u306e\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304b\u3089\u3001LCH\u306e\u6cbb\u7642\u306b\u30a8\u30c8\u30dd\u30b7\u30c9\u304c\u4f7f\u308f\u308c\u308b\u3053\u3068\u306f\u3001\u307b\u3068\u3093\u3069\u306a\u304f\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>1990\u5e74\u4ee3\u304b\u3089\u884c\u308f\u308c\u3066\u304d\u305f\u56fd\u969b\u7d44\u7e54\u7403\u5b66\u4f1a\uff08<a href=\"https:\/\/www.ishamachi.com\/?p=89676\">Histiocyte Society<\/a>\uff09\u306b\u3088\u308b\u56fd\u969b\u81e8\u5e8a\u8a66\u9a13\uff08Gadner H, 2001; 2008; 2013\uff09\u306e\u6cbb\u7642\u85ac\u306f\u3001<strong>\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3<\/strong>\u3068\u3044\u3046\u30d3\u30f3\u30ab\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u3068<strong>\u30d7\u30ec\u30c9\u30cb\u30be\u30ed\u30f3<\/strong>\u304c\u4e2d\u5fc3\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u5f53\u521d\u306f\u30a8\u30c8\u30dd\u30b7\u30c9\u3082\u7d44\u307f\u8fbc\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u524d\u8ff0\u306e\u3088\u3046\u306a\u7406\u7531\u304b\u3089\u4f7f\u308f\u308c\u306a\u304f\u306a\u308a\u307e\u3057\u305f\u3002\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3\u3068\u30d7\u30ec\u30c9\u30cb\u30be\u30ed\u30f3\u3068\u3044\u3046\u7d44\u307f\u5408\u308f\u305b\u306f\u3001\u708e\u75c7\u7d30\u80de\u3092\u304a\u3068\u306a\u3057\u304f\u3055\u305b\u308b\u52b9\u679c\u306f\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u304c\u3001LCH\u7d30\u80de\u3092\u76f4\u63a5\u3084\u3063\u3064\u3051\u308b\u52b9\u679c\u306f\u4e4f\u3057\u3044\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n<p>1990\u5e74\u4ee3\u521d\u3081\u306b\u30aa\u30e9\u30f3\u30c0\u306eEgeler\u3055\u3093\u3089\u304c\u3001\u30b7\u30bf\u30e9\u30d3\u30f3\u3068\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u3001\u30d7\u30ec\u30c9\u30cb\u30be\u30ed\u30f3\u306e\u7d44\u307f\u5408\u308f\u305b\u304c<strong>\u809d\u81d3\u307e\u305f\u306f\u813e\u81d3\u30fb\u9020\u8840\u5668\u306b\u75c5\u5909\u304c\u3042\u308b\u591a\u81d3\u5668\u578b\uff08\u30ea\u30b9\u30af\u81d3\u5668\u6d78\u6f64\u967d\u6027\u591a\u81d3\u5668\u578b\u3068\u547c\u3073\u307e\u3059\uff09<\/strong>\u306eLCH\u306b\u6709\u52b9\u3067\u306f\u306a\u3044\u304b\u3068\u5831\u544a\u3057\u307e\u3057\u305f\uff08Egeler MR, 1993\uff09\u3002\u305d\u3053\u3067\u3001\u65e5\u672cLCH\u7814\u7a76\u4f1a\u3067\u306f1996\u5e74\u304b\u3089\u3001\u591a\u767a\u306e\u9aa8\u304a\u3088\u3073\u591a\u81d3\u5668\u578b\u306eLCH\u306e\u60a3\u8005\u3055\u3093\u3092\u5bfe\u8c61\u306b\u3001\u3053\u306e3\u3064\u306e\u85ac\u3092\u4e2d\u5fc3\u3068\u3057\u305f30\u9031\u9593\u306e\u81e8\u5e8a\u8a66\u9a13\uff08<strong>JLSG-96<\/strong>\uff09\u3092\u958b\u59cb\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u6cbb\u7642\u306b\u3088\u3063\u3066\u3001\u305d\u308c\u307e\u306720\uff05\u8fd1\u304b\u3063\u305f\u591a\u81d3\u5668\u578bLCH\u306e\u60a3\u8005\u3055\u3093\u306e\u6b7b\u4ea1\u7387\u306f5\uff05\u307e\u3067\u4f4e\u4e0b\u3057\u3001\u5287\u7684\u306a\u52b9\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\uff08Morimoto A, 2006\uff09\u3002<\/p>\n<p>\u3057\u304b\u3057\u4f9d\u7136\u3068\u3057\u3066\u3001\u591a\u81d3\u5668\u578b\u306e\u60a3\u8005\u3055\u3093\u306e\u534a\u6570\u306f\u518d\u767a\u3057\u307e\u3057\u305f\u3002\u305d\u3053\u30672002\u5e74\u304b\u3089\u306f\u3001\u6cbb\u7642\u671f\u9593\u309254\u9031\u9593\u306b\u5ef6\u9577\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\uff08<strong>JLSG-02<\/strong>\uff09\u3092\u884c\u3044\u3001\u3053\u308c\u306b\u3088\u3063\u3066\u591a\u81d3\u5668\u578b\u306e\u518d\u767a\u7387\u306f30\uff05\u307e\u3067\u4f4e\u4e0b\u3057\u307e\u3057\u305f\uff08Morimoto A, 2016\uff09\u3002\u3053\u306e\u6210\u7e3e\u306f\u3001\u56fd\u969b\u81e8\u5e8a\u8a66\u9a13\u3088\u308a\u3082\u826f\u597d\u3067\u3059\u3002<\/p>\n<p>\u958b\u59cb\u5f53\u6642\u306f\u3001\u307e\u3060LCH\u306e\u6b63\u4f53\u304c\u826f\u304f\u308f\u304b\u3063\u3066\u3044\u306a\u304b\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u4eca\u8003\u3048\u308b\u3068\u3001<strong>\u6297\u816b\u760d\u3068\u6297\u708e\u75c7\u306e\u4e21\u65b9\u3092\u76ee\u6307\u3057\u305f\u6cbb\u7642<\/strong>\u3067\u3042\u308a\u3001\u5148\u898b\u306e\u660e\u304c\u3042\u3063\u305f\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>JLSG-02\u306e\u6cbb\u7642\u5185\u5bb9\u306f\u3001\u65e5\u672cLCH\u7814\u7a76\u4f1a\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8\uff08<a href=\"http:\/\/www.jlsg.jp\/\">http:\/\/www.jlsg.jp\/<\/a>\uff09\u306b\u63b2\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h2>\uff14\uff0e\u521d\u671f\u6cbb\u7642\u304c\u52b9\u304b\u306a\u3044\u3068\u304d\u306f\u3069\u3046\u3059\u308b\u304b\uff1f<\/h2>\n<p>\u30ea\u30b9\u30af\u81d3\u5668\u6d78\u6f64\u967d\u6027\u591a\u81d3\u5668\u578b\u306e\u60a3\u8005\u3055\u3093\u306e\u5834\u5408\u3001\u524d\u8ff0\u306e\u30b7\u30bf\u30e9\u30d3\u30f3\/\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\/\u30d7\u30ec\u30c9\u30cb\u30be\u30ed\u30f3\u306b\u3088\u308b\u6cbb\u7642\u30926\u9031\u9593\u884c\u3063\u3066\u3082\u3001\u7d041\/4\u306e\u60a3\u8005\u3055\u3093\u306f\u3001\u826f\u304f\u306a\u308a\u307e\u305b\u3093\u3002\u3053\u306e\u3088\u3046\u306a\u60a3\u8005\u3055\u3093\u306e30\uff05\u306f\u4ea1\u304f\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n<p>\u521d\u671f\u6cbb\u7642\u3067\u3088\u304f\u306a\u3089\u306a\u3044\u3001\u30ea\u30b9\u30af\u81d3\u5668\u6d78\u6f64\u967d\u6027\u591a\u81d3\u5668\u578b\u306e\u60a3\u8005\u3055\u3093\u306b\u5bfe\u3057\u3066\u306f\u3001<strong>\u5927\u91cf\u30b7\u30bf\u30e9\u30d3\u30f3\u3068\u30af\u30e9\u30c9\u30ea\u30d3\u30f3\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u6cbb\u7642<\/strong>\uff08Donadieu J, 2015\uff09\u304c\u8a66\u307f\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u6cbb\u7642\u306b\u3088\u308a\u3001\u521d\u671f\u6cbb\u7642\uff08\u3053\u306e\u5834\u5408\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3\uff0b\u30d7\u30ec\u30c9\u30cb\u30be\u30ed\u30f3\uff09\u304c\u52b9\u304b\u306a\u304b\u3063\u305f\u60a3\u8005\u3055\u3093\u306e90%\u4ee5\u4e0a\u3067\u52b9\u679c\u304c\u5f97\u3089\u308c\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u8457\u3057\u3044\u9aa8\u9ac4\u6291\u5236\uff08\u8ca7\u8840\u30fb\u767d\u8840\u7403\u3068\u8840\u5c0f\u677f\u306e\u6e1b\u5c11\uff09\u306e\u526f\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u306e\u3067\u3001\u5b89\u6613\u306b\u306f\u884c\u3048\u307e\u305b\u3093\u3002<\/p>\n<p>\u7a76\u6975\u306e\u6cbb\u7642\u3068\u3057\u3066\u3001<strong>\u540c\u7a2e\u9020\u8840\u7d30\u80de\u79fb\u690d<\/strong>\u304c\u3042\u308a\u307e\u3059\u3002LCH\u7d30\u80de\u306f\u8840\u6db2\u7531\u6765\u306e\u7d30\u80de\u306a\u306e\u3067\u3001<strong>\u8840\u6db2\u3092\u307e\u308b\u3054\u3068\u5165\u308c\u66ff\u3048\u3088\u3046<\/strong>\u3068\u3044\u3046\u308f\u3051\u3067\u3059\u3002\u79fb\u690d\u524d\u306b\u75c5\u52e2\u304c\u843d\u3061\u7740\u3044\u3066\u3044\u308b\u72b6\u614b\u3067\u3042\u308c\u3070\u3001\u5f37\u5ea6\u6e1b\u5f31\u524d\u51e6\u7f6e\uff08RIC\uff09<sup>\u203b<\/sup>\u3067\u3082\u5341\u5206\u3046\u307e\u304f\u3044\u304d\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u75c5\u52e2\u304c\u843d\u3061\u7740\u3044\u3066\u3044\u306a\u3044\u3001\u3059\u306a\u308f\u3061\u3001\u514d\u75ab\u7cfb\u304c\u6d3b\u767a\u306b\u306a\u308a\u3059\u304e\u3066\u3044\u308b\u72b6\u614b\u3067\u79fb\u690d\u3092\u3057\u3066\u3082\u3001\u62d2\u7d76\u3084\u81d3\u5668\u969c\u5bb3\u304c\u304a\u304d\u3066\u3057\u307e\u3044\u3001\u79fb\u690d\u304c\u3046\u307e\u304f\u3044\u304b\u306a\u3044\u3053\u3068\u304c\u3057\u3070\u3057\u3070\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><span style=\"font-size: 10pt;\">\u203b\u79fb\u690d\u3092\u884c\u3046\u969b\u3001\u60a3\u8005\u3055\u3093\u306e\u4f53\u5185\u306e\u304c\u3093\u7d30\u80de\u3092\u3067\u304d\u308b\u3060\u3051\u5c11\u306a\u304f\u3059\u308b\u305f\u3081\u3001\u307e\u305f\u3001\u63d0\u4f9b\u8005\u306e\u9020\u8840\u7d30\u80de\u3092\u60a3\u8005\u3055\u3093\u306e\u4f53\u306b\u5b9a\u7740\u3055\u305b\u308b\u305f\u3081\u306b\u30011\u9031\u9593\u307b\u3069\u524d\u304b\u3089\u3001\u6297\u816b\u760d\u85ac\u3084\u5168\u8eab\u653e\u5c04\u7dda\u7167\u5c04\u306a\u3069\u7528\u3044\u305f\u51e6\u7f6e\uff08\u524d\u51e6\u7f6e\uff09\u3092\u884c\u3044\u307e\u3059\u3002\u5f37\u5ea6\u6e1b\u5f31\u524d\u51e6\u7f6e\u306f\u3001\u526f\u4f5c\u7528\u306e\u8efd\u6e1b\u3092\u56f3\u308b\u305f\u3081\u306b\u3001\u5f93\u6765\u3088\u308a\u3082\u524d\u51e6\u7f6e\u306e\u5f37\u5ea6\u3092\u5f31\u3081\u305f\u3082\u306e\u3067\u3059\u3002<\/span><\/p>\n<h2>\uff15\uff0e\u518d\u767a\u6642\u306e\u6cbb\u7642\u306f\u3069\u3046\u3059\u308b\u304b\uff1f<\/h2>\n<p>LCH\u306f\u3057\u3070\u3057\u3070<a href=\"https:\/\/www.ishamachi.com\/?p=91287\">\u518d\u767a<\/a>\u3059\u308b\u75c5\u6c17\u3067\u3059\u3002\u518d\u767a\u3057\u3066\u3082\u3001\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u306f\u6cbb\u7642\u304c\u52b9\u3044\u3066\u3088\u304f\u306a\u308a\u307e\u3059\u3002\u3067\u3082\u307e\u305f\u518d\u767a\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u518d\u767a\u90e8\u4f4d\u306f\u591a\u304f\u304c\u9aa8\u3067\u3059\u3002\u591a\u81d3\u5668\u306b\u518d\u767a\u3057\u305f\u5834\u5408\u306b\u306f\u3001\u4e00\u304b\u3089\u6cbb\u7642\u3092\u3084\u308a\u76f4\u3059\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u9aa8\u3060\u3051\u306e\u518d\u767a\u306e\u5834\u5408\u306b\u306f\u3001\u901a\u9662\u3067\u53ef\u80fd\u306a\u8efd\u3081\u306e\u6cbb\u7642\u3092\u9078\u3076\u3053\u3068\u304c\u591a\u304f\u306a\u308a\u307e\u3059\u3002\u983b\u56de\u306b\u9aa8\u306b\u518d\u767a\u3059\u308b\u4f8b\u306b\u306f\u3001<strong>\u30d3\u30b9\u30d5\u30a9\u30b9\u30d5\u30a9\u30cd\u30fc\u30c8\u88fd\u5264<\/strong>\u3068\u3044\u3046\u7834\u9aa8\u7d30\u80de\u3092\u6291\u3048\u308b\u85ac\u304c\u4f7f\u308f\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\uff08Morimoto A, 2011\uff09\u3002<\/p>\n<h2>\uff16\uff0e\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u306f\u3069\u3046\u3067\u3057\u3087\u3046\uff1f<\/h2>\n<p>\u7d04\u534a\u6570\u306e\u60a3\u8005\u3055\u3093\u306b\u306f\u3001LCH\u7d30\u80de\u306b<strong><em>BRAF<\/em><\/strong><strong>\u907a\u4f1d\u5b50\u306e\u767a\u304c\u3093\u6027\u5909\u7570<\/strong>\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u3070\u3057\u3070<em>BRAF<\/em>\u907a\u4f1d\u5b50\u306b\u5909\u7570\u3092\u8a8d\u3081\u308b\u60aa\u6027\u9ed2\u8272\u816b\u3067\u306f\u3001<em>BRAF<\/em>\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u6291\u3048\u308b\u5185\u670d\u85ac\uff08<strong>\u30d9\u30e0\u30e9\u30d5\u30a7\u30cb\u30d6\u306a\u3069<\/strong>\uff09\u304c\u5b9f\u969b\u306b\u6cbb\u7642\u306b\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>LCH\u3067\u3082\u3001\u6297\u816b\u760d\u85ac\u306b\u3088\u308b\u6cbb\u7642\u304c\u52b9\u304b\u306a\u3044<em>BRAF<\/em>\u5909\u7570\u967d\u6027\u306e\u30ea\u30b9\u30af\u81d3\u5668\u6d78\u6f64\u967d\u6027\u591a\u81d3\u5668\u578b\u306e\u60a3\u8005\u3055\u3093\u306b\u3001\u30d9\u30e0\u30e9\u30d5\u30a7\u30cb\u30d6\u3092\u5185\u670d\u3057\u305f\u3068\u3053\u308d\u75c7\u72b6\u304c\u826f\u304f\u306a\u3063\u305f\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002\u4eca\u307e\u3067\u306b<em>BRAF<\/em>\u5909\u7570\u967d\u6027\u306e\u5c0f\u5150LCH\u306b\u30d9\u30e0\u30e9\u30d5\u30a7\u30cb\u30d6\u4f7f\u3063\u305f\u5831\u544a\u306f10\u4f8b\u307b\u3069\u3042\u308a\u3001\u307b\u3068\u3093\u3069\u3059\u3079\u3066\u306e\u4f8b\u3067\u5927\u304d\u306a\u526f\u4f5c\u7528\u306a\u304f\u52b9\u679c\u304c\u5f97\u3089\u308c\u3066\u3044\u307e\u3059\uff08Heisig A, 2018\uff09\u3002\u3057\u304b\u3057\u3001\u4f55\u304b\u6708\u304b\u3067\u85ac\u3092\u6b62\u3081\u305f\u60a3\u8005\u3055\u3093\u306f\u3059\u3079\u3066\u518d\u767a\u3057\u3066\u304a\u308a\u3001\u3069\u306e\u304f\u3089\u3044\u306e\u671f\u9593\u98f2\u307f\u7d9a\u3051\u306a\u304f\u3066\u306f\u3044\u3051\u306a\u3044\u306e\u304b\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p>\u30d9\u30e0\u30e9\u30d5\u30a7\u30cb\u30d6\u306f\u3001\u9020\u8840\u7d30\u80de\u79fb\u690d\u3092\u3059\u308b\u524d\u306b\u75c5\u52e2\u3092\u5b89\u5b9a\u3055\u305b\u308b\u306e\u306b\u9069\u3057\u305f\u6cbb\u7642\u6cd5\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u73fe\u5728\u6d77\u5916\u3067LCH\u306b\u5bfe\u3059\u308b\u30d9\u30e0\u30e9\u30d5\u30a7\u30cb\u30d6\u306e\u6cbb\u9a13\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u85ac\u306e\u627f\u8a8d\u306f\u307e\u3060\u5148\u306b\u306a\u308a\u305d\u3046\u3067\u3059\u3002<\/p>\n<h2>\uff17\uff0e\u4eca\u5f8c\u306e\u81e8\u5e8a\u8a66\u9a13\u306f\u3069\u3046\u306a\u308b\u306e\uff1f<\/h2>\n<p><strong>LCH<\/strong><strong>\u306e\u6cbb\u7642\u306f\u3053\u306e\u56db\u534a\u4e16\u7d00\u3067\u5927\u304d\u304f\u9032\u6b69\u3057\u307e\u3057\u305f\u3002<\/strong>\u3053\u308c\u306f\u3001\u3088\u308a\u3088\u3044\u6cbb\u7642\u3092\u76ee\u6307\u3057\u3066\u3001\u81e8\u5e8a\u8a66\u9a13\u304c\u7a4d\u307f\u91cd\u306d\u3089\u308c\u3066\u304d\u305f\u7d50\u679c\u3067\u3059\u3002\u4eca\u6b8b\u3055\u308c\u3066\u3044\u308b\u8ab2\u984c\u3068\u3057\u3066\u306f\u3001\u4e0b\u8a18\u306e\u4e09\u70b9\u304c\u6319\u3052\u3089\u308c\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<ol>\n<li>\u30ea\u30b9\u30af\u81d3\u5668\u6d78\u6f64\u967d\u6027\u591a\u81d3\u5668\u578b\u3067\u521d\u671f\u6cbb\u7642\u53cd\u5fdc\u4e0d\u826f\u4f8b\u306e\u6b7b\u4ea1\u7387\u304c\u9ad8\u3044\u306e\u3067\u3001\u521d\u671f\u6cbb\u7642\u306e\u594f\u529f\u7387\u3092\u4e0a\u3052\u308b\u306b\u306f\u3069\u3046\u3057\u305f\u3089\u3088\u3044\u304b\uff1f<\/li>\n<li>\u91cd\u5927\u306a\u6669\u671f\u5408\u4f75\u75c7\u3067\u3042\u308b\u4e2d\u67a2\u6027\u5c3f\u5d29\u75c7\u3084\u4e2d\u67a2\u795e\u7d4c\u5909\u6027\u75c7\u3092\u6e1b\u3089\u3059\u306b\u306f\u3069\u3046\u3057\u305f\u3089\u3088\u3044\u304b\uff1f<\/li>\n<li>\u518d\u767a\u304c\u672a\u3060\u591a\u3044\u306e\u3067\u3001\u305d\u306e\u591a\u304f\u3092\u5360\u3081\u308b\u9aa8\u518d\u767a\u3092\u6e1b\u3089\u3059\u306b\u306f\u3069\u3046\u3057\u305f\u3089\u3088\u3044\u304b\uff1f<\/li>\n<\/ol>\n<p>\u3053\u308c\u3089\u3092\u89e3\u6c7a\u3059\u308b\u305f\u3081\u4ee5\u4e0b\u306e\u4eee\u8aac\u3092\u7acb\u3066\u3066\u3001\u81e8\u5e8a\u8a66\u9a13\u3092\u8a08\u753b\u4e2d\u3067\u3059\u3002<\/p>\n<h3>\uff11\uff09\u521d\u671f\u6cbb\u7642\u306e\u594f\u529f\u7387\u3092\u4e0a\u3052\u308b\u306b\u306f<\/h3>\n<p><strong>\u521d\u671f\u6cbb\u7642\u306e\u5f37\u5316<\/strong>\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u6297\u816b\u760d\u85ac\u3092\u5f37\u304f\u3057\u3059\u304e\u308b\u3068\u526f\u4f5c\u7528\u304c\u5927\u304d\u306a\u554f\u984c\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u4f8b\u3067\u306f\u3001\u904e\u5270\u306a\u708e\u75c7\u306b\u3088\u308b\u81d3\u5668\u969c\u5bb3\u304c\u6b7b\u56e0\u306b\u306a\u308b\u3053\u3068\u304c\u591a\u3044\u306e\u3067\u3001\u6297\u708e\u75c7\u3092\u5f37\u5316\u3059\u308b\u307b\u3046\u304c\u3001\u7406\u306b\u304b\u306a\u3063\u3066\u3044\u308b\u3088\u3046\u306b\u601d\u308f\u308c\u307e\u3059\u3002\u305d\u3053\u3067\u3001\u4e00\u822c\u306b\u4f7f\u308f\u308c\u308b\u30d7\u30ec\u30c9\u30cb\u30be\u30ed\u30f3\u3092\u3001\u3088\u308a\u6297\u708e\u75c7\u52b9\u679c\u304c\u9ad8\u3044\u30c7\u30ad\u30b5\u30e1\u30bf\u30be\u30f3\u306b\u5165\u308c\u66ff\u3048\u308c\u3070\u3001\u521d\u671f\u6cbb\u7642\u53cd\u5fdc\u304c\u826f\u304f\u306a\u308b\u306e\u3067\u306f\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3>\uff12\uff09\u4e2d\u67a2\u6027\u5c3f\u5d29\u75c7\u3084\u4e2d\u67a2\u795e\u7d4c\u5909\u6027\u75c7\u3092\u6e1b\u3089\u3059\u306b\u306f<\/h3>\n<p><strong>\u4e2d\u67a2\u795e\u7d4c\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642<\/strong>\u3092\u5c0e\u5165\u3059\u3079\u304d\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u8133\u306f\u8133\u8840\u6db2\u95a2\u9580\u3068\u3044\u3046\u30d0\u30ea\u30a2\u306b\u3088\u3063\u3066\u3001\u6297\u816b\u760d\u85ac\u306a\u3069\u306e\u5316\u5b66\u7269\u8cea\u304b\u3089\u5b88\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u8a00\u3044\u63db\u3048\u308c\u3070\u3001<strong>\u8133\u306e\u4e2d\u306f\u6297\u816b\u760d\u85ac\u304c\u5c4a\u304d\u306b\u304f\u304f\u3001\u6cbb\u7642\u52b9\u679c\u304c\u5341\u5206\u3067\u306a\u3044<\/strong>\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u6700\u8fd1\u3001LCH\u7d30\u80de\u3068\u540c\u3058\u767a\u304c\u3093\u6027\u907a\u4f1d\u5b50\u3092\u6301\u3063\u305f<strong>\u9aa8\u9ac4\u7cfb\u7d30\u80de\uff08\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\uff09<\/strong>\u306b\u3088\u3063\u3066\u4e2d\u67a2\u795e\u7d4c\u5909\u6027\u75c7\u304c\u5f15\u304d\u8d77\u305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